The Department of Molecular, Cellular and Biomedical Sciences provides an education based on research and scientific information, intended to meet the needs of those interested in the biomedical and molecular/cellular life sciences.
Faculty may submit research here.
Submissions from 2008
Pyomelanin is produced by Shewanella algae BrY and affected by exogenous iron, Charles E. Turick, Frank Caccavo, and Louis S. Tisa
Submissions from 2007
Permeating protons contribute to tachyphylaxis of the acid-sensing ion channel (ASIC) 1a, Xuanmao Chen and Stefan Grunder
Zebrafish acid-sensing ion channel (ASIC) 4, characterization of homo- and heteromeric channels, and identification of regions important for activation by H+, Xuanmao Chen, Georg Polleichtner, Ivan Kadurin, and Stefan Grunder
Microfracture Surface Geochemistry and Adherent Microbial Population Metabolism in TCE-Contaminated Competent Bedrock, T. Taylor Eighmy, Jean C. M. Spear, Julia Case, Michelle Mills, Kimberly Newman, Nancy E. Kinner, Hallie Marbet, Jose Casas, Wallace Bothner, Joanne Coulburn, Louis S. Tisa, Michelle Majko, Elise R. Sullivan, and Mary E. Gonsoulin
Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity, Yizhou Liu, Wei Chen, Justin Gaudet, Thomas M. Laue, Nancy A. Speck, and John H. Bushweller
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography, Philippe Normand, Pascal Lapierre, Louis S. Tisa, Johann P. Gogarten, Nicole Alloisio, Emilie Bagnarol, Carla A. Bassi, Alison M. Berry, Derek M. Bickhart, Nathalie Choisne, Arnaud Couloux, Benoit Cournoyer, Stephane Cruveiller, Vincent Daubin, Nadia Demange, Maria Pilar Francino, Eugene Goltsman, Ying Huang, Olga R. Kopp, and Laurent Labarre
Exploring the genomes of Frankia, Philippe Normand, Clothilde Queiroux, Louis S. Tisa, David R. Benson, Zoe Rouy, Stephane Cruveiller, and Claudine Medigue
CAF1 plays an important role in mRNA deadenylation separate from its contact to CCR4, Takbum Ohn, Yueh-Chin Chiang, Darren J. Lee, Gang Yao, Chongxu Zhang, and Clyde L. Denis
Analysis of codon usage patterns and predicted highly expressed genes for six phytopathogenic Xanthomonas genomes shows a high degree of conservation, Gargi Sen, Saubashya Sur, Debadin Bose, Uttam Mondal, Teal Furnholm, Asim Bothra, Louis S. Tisa, and Arnab Sen
Living Large: Elucidation of the Frankia EAN1pec Genome Sequence Shows Gene Expansion and Metabolic Versatility, Louis S. Tisa, David R. Benson, G. B. Smejkal, Pascal Lapierre, Johann P. Gogarten, Philippe Normand, Maria Pilar Francino, and P. Richardson
Submissions from 2006
Interaction of acid-sensing ion channel (ASIC) 1 with the tarantula toxin psalmotoxin 1 is state dependent, Xuanmao Chen, Hubert Kalbacher, and Stefan Grunder
Strong modulation by RFamide neuropeptides of the ASIC1b/3 heteromer in competition with extracellular calcium, Xuanmao Chen, Martin Paukert, Ivan Kadurin, Michael Pusch, and Stefan Grunder
Microfracture Surface Characterizations: Implications for In Situ Remedial Methods in Fractured Rock, T. Taylor Eighmy, Jean C. M. Spear, Julia Case, Hallie Marbet, Jose Casas, Wallace Bothner, Joanne Coulburn, Louis S. Tisa, M. Majko, E. Sullivan, Michelle Mills, Kimberly Newman, and N. E. Kinner
Astacin family metallopeptidases and serine peptidase inhibitors in spider digestive fluid, Matthew J. Foradori, Edward K. Tillinghast, J. Stephen Smith, Mark A. Townley, and Robert E. Mooney
A Light Intensity Measurement System for the Analytical Ultracentrifuge, Thomas M. Laue, Joseph B. Austin, and David A. Rau
The glutamic acid-rich protein-2 (GARP2) is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties., Dana C. Pentia, Suzanne Hosier, and Rick H. Cote
Changes in composition of spider orb web sticky droplets with starvation and web removal, and synthesis of sticky droplet compounds, Mark A. Townley, Edward K. Tillinghast, and Christopher D. Neefus
Immune cell-endothelial cell interactions in the bovine corpus luteum, David H. Townson
Submissions from 2005
Rod and cone opsin families differ in spectral tuning domains but not signal transducing domains as judged by saturated evolutionary trace analysis., Karen L. Carleton, Tyrone C. Spady, and Rick H. Cote
The tarantula toxin psalmotoxin 1 inhibits acid-sensing ion channel (ASIC) 1a by increasing its apparent H+ affinity, Xuanmao Chen
Cyclic Guanosine 5′-Monophosphate Binding to Regulatory GAF Domains of Photoreceptor Phosphodiesterase, Rick H. Cote
Microbial processes in fractured rock environments, Nancy E. Kinner, T. Taylor Eighmy, Michelle Mills, Joanne Coulburn, and Louis S. Tisa
Cooperative expression of monocyte chemoattractant protein 1 within the bovine corpus luteum: Evidence of immune cell-endothelial cell interactions in a coculture system, Amy R. Liptak, Brian T. Sullivan, Luiz E. Henkes, Missaka P.B. Wijayagunawardane, Akio Miyamoto, John S. Davis, Bo R. Rueda, and David H. Townson
Valence and anion binding of bovine ribonuclease A between pH 6 and 8, Thomas P. Moody, Jonathan S. Kingsbury, Jennifer A. Durant, Timothy J. Wilson, Susan F. Chase, and Thomas M. Laue
Identification of the Truncated Hemoglobin Gene in Frankia, J. M. Niemann, John D. Tjepkema, and Louis S. Tisa
Purification of PDE6 isozymes from mammalian retina., Dana C. Pentia, Suzanne Hosier, Rachel A. Collupy, Benerly A. Valeriani, and Rick H. Cote
Age and growth estimates of the thorny skate (Amblyraja radiata) in the western Gulf of Maine, James A. Sulikowski, Jeff Kneebone, Scott Elzey, Joe Jurek, Patrick D. Danley, William Huntting Howell, and Paul C.W. Tsang
The reproductive cycle of the thorny skate (Amblyraid radiata) in the western Gulf of Maine, James A. Sulikowski, Jeff Kneebone, Scott Elzey, Joe Jurek, Patrick D. Danley, William Huntting Howell, and Paul C.W. Tsang
Assay and functional properties of PrBP(PDEδ), a prenyl-binding protein interacting with multiple partners., Houbin Zhang, Suzanne Hosier, Jennifer M. Terew, Kai Zhang, Rick H. Cote, and Wolfgang Baehr
Submissions from 2004
Iron binding and oxidation kinetics in frataxin CyaY of Escherichia coli, Fadi Bou-Abdallah, Salvatore Adinolfi, Annalisa Pastore, Thomas M. Laue, and N. Dennis Chasteen
Community profiling of bacterial endosymbionts in four species of Caulerpa, L. Delridge, Joanne Coulburn, W. Fagerberg, and Louis S. Tisa
Solution structure of the coxsackievirus and adenovirus receptor domain 1, Shaokai Jiang, Amy Jacobs, Thomas M. Laue, and Michael Caffrey
Analytical Ultracentrifugation: A Powerful ‘New’ Technology, Thomas M. Laue
Fluorescence detection for the XLI analytical ultracentrifuge, Ian K. MacGregor, Arthur L. Anderson, and Thomas M. Laue
Submissions from 2003
Role of Protein-Protein Bridging Interactions on Cooperative Assembly of DNA-Bound CRP-CytR-CRP Complex and Regulation of the Escherichia Coli CytR Regulon, Mayy Chahla, John O. Wooll, Thomas M. Laue, Nghia Nguyen, and Donald F. Senear
Regulation of cyclic nucleotide levels by sequestration., Jackie D. Corbin, Jun Kotera, Venkatesh Gopal, Rick H. Cote, and Sharron H. Francis
Structure, function, and regulation of photoreceptor phosphodiesterase (PDE6)., Rick H. Cote
On the use of ampullate gland silks by wolf spiders (Araneae, Lycosidae) for attaching the egg sac to the spinnerets and a proposal for defining nubbins and tartipores, Mark A. Townley and Edward K. Tillinghast
Chemokines in the corpus luteum: implications of leukocyte chemotaxis, David H. Townson and Amy R. Liptak
Temporal and spatial expression of tissue inhibitors of metalloproteinases 1 and 2 (TIMP-1 and -2) in the bovine corpus luteum, Bo Zhang, Marsha A. Moses, and Paul C.W. Tsang
Submissions from 2002
Aqueous Processing and Fiber Spinning of Recombinant Spider Silks, Steven Arcidiacono, Charlene M. Mello, Michelle M. Butler, Michelle M. Butler, Jason W. Soares, Alfred Allen, David Ziegler, Thomas M. Laue, and Susan F. Chase
Hemoglobin in five genetically diverse Frankia strains, Jason Beckwith, John D. Tjepkema, Robert E. Cashon, Christa R. Schwintzer, and Louis S. Tisa
Secretion of monocyte chemoattractant protein-1 by endothelial cells of the bovine corpus luteum: Regulation by cytokines but not prostaglandin F2 alpha, Victoria A. Cavicchio, James K. Pru, Benjamin S. Davis, John S. Davis, Bo R. Rueda, and David H. Townson
Use of T4 Lysozyme Charge Mutants to Examine Electrophoretic Models, Jennifer A. Durant, Chuanying Chen, Thomas M. Laue, Thomas P. Moody, and Stuart A. Allison
Characterization of the H and L Subunit Ratios of Ferritins by SDS Capillary Gel Electrophoresis, John K. Grady, Jia Zang, Thomas M. Laue, Paolo Arosio, and N. Dennis Chasteen
Analysis of the Role of the Interleukin-2 Receptor ? Chain in Ligand Binding, Stefano F. Liparoto, David G. Myszka, Zining Wu, Byron Goldstein, Thomas M. Laue, and Thomas L. Ciardelli
Altered affinity of CBF beta-SMMHC for Runx1 explains its role in leukemogenesis, Stephen M. Lukasik, Lina Zhang, Takeshi Corpora, Sarah Tomanicek, Yuanhong Li, Mondira Kundu, Kari Hartman, P. Paul Liu, Thomas M. Laue, Rodney L. Biltonen, Nancy A. Speck, and John H. Bushweller
Developing genetic tools for Frankia, the bacterial partner of the actinorhizal symbiosis, A. Myers, T. Rawnsley, and Louis S. Tisa
Expression of monocyte chemoattractant protein-1 and distribution of immune cell populations in the bovine corpus luteum throughout the estrous cycle, David H. Townson, Cindy L. O'Connor, and James K. Pru
Relationship of fertility to ovarian follicular waves before breeding in dairy cows, D. H. Townson, Paul C.W. Tsang, W. R. Butler, M. Frajblat, L. C. Griel Jr., C. J. Johnson, R. A. Milvae, G. M. Niksic, and J. L. Pate
Iron and Hydrogen Peroxide Detoxification Properties of Dps: A Ferritin-like DNA Binding Protein of Escherichia coli, Guanghua Zhao, Pierpaolo Ceci, Andrea Ilari, Laura Giangiacomo, Thomas M. Laue, Emilia Chiancone, and N. Dennis Chasteen
Submissions from 2001
Variation in the chemical composition of orb webs built by the spider Nephila clavipes (Araneae, Tetragnathidae), Linden E. Higgins, Mark A. Townley, Edward K. Tillinghast, and Mary Ann Rankin
Molecular organization of bovine rod cGMP-Phosphodiesterase 6., Jacques F. Kameni Tcheudji, Luc Lebeau, Noelle Virmaux, Carmen G. Maftei, Rick H. Cote, Claire Lugnier, and Patrick Schultz
Sedimentation, Thomas M. Laue
Actions of prostaglandin F-2 alpha and prolactin on intercellular adhesion molecule-1 expression and monocyte/macrophage accumulation in the rat corpus luteum, Kristen K. Olson, Lori E. Anderson, Milo C. Wiltbank, and David H. Townson
Submissions from 2000
Purification and characterization of a novel calcium binding protein from the extrapallial fluid of mollusc Mytilus edulis, Stephen J. Hattan, Thomas M. Laue, and N. Dennis Chasteen
Analysis of Transport Experiments using Pseudo-absorbance Data, Sambit R. Kar, Jonathan S. Kingsbury, Marc S. Lewis, Thomas M. Laue, and Peter Schuck
Electrostatic Interactions in Leucine Zippers: Effects on Stability and Specificity of Interaction, Kevin P. McGrath, Michelle M. Butler, Carla M. DiGirolamo, David L. Kaplan, Wendy A. Petka, and Thomas M. Laue
Prolactin-induced expression of intercellular adhesion molecule-1 and the accumulation of monocytes/macrophages during regression of the rat corpus luteum, Kristen K. Olson and David H. Townson
Biophysical characterization of interactions between the core binding factor α and β subunits and DNA, Yen-Yee Tang, Barbara E. Crute, John J. Kelley III, Xuemei Huang, Jiangli Yan, Jianxia Shi, Kari L. Hartman, Thomas M. Laue, Nancy A. Speck, and John H. Bushweller
Interaction of ω-conotoxin and the membrane calcium transport system of Escherichia coli, Louis S. Tisa
Effects of Organic Antagonists of Ca2+, Na+, and K+ on Chemotaxis and Motility ofEscherichia coli, Louis S. Tisa, Jeff J. Sekelsky, and Julius Adler
Submissions from 1999
Visualizing Ion Relaxation in the Transport of Short DNA Fragments, Stuart A. Allison, Hua Wang, Thomas M. Laue, Timothy J. Wilson, and John O. Wooll
Characterization of the Self Association of Avian Sarcoma Virus Integrase by Analytical Ultracentrifugation, Jacqueline Coleman, Steven F. Eaton, George W. Merkel, Anna M. Skalka, and Thomas M. Laue
Analytical Centrifugation: Equilibrium Approach, Thomas M. Laue
Modern Applications of Analytical Ultracentrifugation, Thomas M. Laue and Walter F. Stafford III
Rotational and Translational Motion of Troponin C, Martin C. Moncrieffe, Steven F. Eaton, Zelijko Bajzer, Christopher Haydock, Thomas M. Laue, and Franklyn G. Prendergast
Antibiotic resistance patterns of Frankia strains, Louis S. Tisa, Matthew S. Chval, Glenn D. Krumholz, and Joel Richards
Solution Assembly of the Pseudo-high Affinity and Intermediate Affinity Interleukin-2 Receptor Complexes, Zining Wu, Byron Goldstein, Thomas M. Laue, Stefano F. Liparoto, Michael J. Nemeth, and Thomas L. Ciardelli
Submissions from 1998
Photoreceptor phosphodiesterase: Interaction of inhibitory γ subunit and cyclic GMP with specific binding sites on catalytic subunits., Nikolai O. Artemyev, Vadim Y. Arshavsky, and Rick H. Cote
Overexpression, Purification, and Biophysical Characterization of the Heterodimerization Domain of the Core-binding Factor β Subunit, Xuemei Huang, Barbara E. Crute, Chaohong Sun, Yen-Yee Tang, John J. Kelley III, Amy F. Lewis, Kari L. Hartman, Thomas M. Laue, Nancy A. Speck, and John H. Bushweller
Membrane-Confined Analytical Electrophoresis, Thomas M. Laue, Harvey K. Shepard, Theresa M. Ridgeway, Thomas P. Moody, and Timothy J. Wilson
An Apparatus for Membrane-confined Analytical Electrophoresis, Theresa M. Ridgeway, David B. Hayes, Thomas P. Moody, Timothy J. Wilson, Arthur L. Anderson, John H. Levasseur, Phillip D. Demaine, Burt E. Kenty, and Thomas M. Laue
Analysis of Protein and DNA-Mediated Contributions to Cooperative Assembly of Protein–DNA Complexes, Donald F. Senear, J. B. Alexander Ross, and Thomas M. Laue
Calcium Transport by Frankia sp. Strain EAN1pec, Louis S. Tisa
Submissions from 1997
Advances in Sedimentation Velocity Analysis, Thomas M. Laue
Prototype Fluorescence Detector for the XLA Analytical Ultracentrifuge, Thomas M. Laue, Arthur L. Anderson, and Bryan J. Weber
Soluble Monomeric P-selectin Containing only the Lectin and EGF Domains Binds to PSGL-1 on Leukocytes, Padmaja Mehta, Kamala D. Patel, Thomas M. Laue, Harold P. Erickson, and Rodger P. McEver
Characterization of a Helix-Loop-Helix (EF Hand) Motif of Silver Hake Parvalbumin Isoform B, Sandra P. Revett, Donald J. Nelson, Gina King, Jeffrey Shabanowitz, Donald F. Hunt, Thomas M. Laue, and Kari L. Hartman
Linkage between Operator Binding and Dimer to Octamer Self-Assembly of Bacteriophage λ cI Repressor†, Elena Rusinova, J. B. Alexander Ross, Thomas M. Laue, Lawrence C. Sowers, and Donald F. Senear
Determination of Macroion Diffusion Coefficients using an Analytical Electrophoresis Apparatus, Harvey K. Shepard, Timothy J. Wilson, Thomas P. Moody, John O. Wooll, and Thomas M. Laue
Assembly of a rod-shaped chimera of a trimeric GCN4 zipper and the HIV-1 gp41 ectodomain expressed in Escherichia coli, Winfried Weissenhorn, Lesley J. Calder, Andrea Dessen, Thomas M. Laue, and John J. Skehel
Submissions from 1996
Analytical Ultracentrifugation, Thomas M. Laue
Insights from a New Analytical Electrophoresis Apparatus, Thomas M. Laue, Theresa M. Ridgeway, John O. Wooll, Harvey K. Shepard, Thomas P. Moody, Timothy J. Wilson, Jonathan B. Chaires, and David A. Stevenson
Turbidometric Studies of Limulus Coagulin Gel Formation, Thomas P. Moody, Maribeth A. Donovan, and Thomas M. Laue
Solution Assembly of Cytokine Receptor Ectodomain Complexes, Zining Wu, Kirk W. Johnson, Byron Goldstein, Thomas M. Laue, and Thomas L. Ciardelli
Submissions from 1995
Sedimentation Equilibrium as a Thermodynamic Tool, Thomas M. Laue
MyoD forms Micelles Which Can Dissociate to Form Heterodimers with E47. Implications of Micellization on Function, Thomas M. Laue, Melissa A. Starovasnik, Harold Weintraub, Xiao-Hong Sun, Lauren Snider, and Rachel E. Klevit
Chemotactic properties of Escherichia coli mutants having abnormal Ca2+ content, Louis S. Tisa and Julius Adler
Cytoplasmic free-Ca2+ level rises with repellents and falls with attractants in Escherichia coli chemotaxis, Louis S. Tisa and Julius Adler
Solution Assembly of a Soluble, Heteromeric, High Affinity Interleukin-2 Receptor Complex, Zining Wu, Kirk W. Johnson, Byron Goldstein, Yoon Choi, Steven F. Eaton, Thomas M. Laue, and Thomas L. Ciardelli
Submissions from 1994
Biochemical Diagnostic Instrumentation, Robert F. Bonner, Gerald E. Cohn, Thomas M. Laue, and Alexander V. Priezzhev
Regulation of intracellular cyclic GMP concentration by light and calcium in electropermeabilized rod photoreceptors., V J. Coccia and Rick H. Cote
cGMP binding sites on photoreceptor phosphodiesterase: role in feedback regulation of visual transduction., Rick H. Cote, M Deric Bownds, and Vadim Y. Arshavsky
Interaction of the Catalytic and the Membrane Subunits of an Oxyanion-Translocating ATPase, Saibal Dey, Dexian Dou, Louis S. Tisa, and Barry P. Rosen
Excitatory actions of FMRFamide-related peptides (FaRPs) on the neurogenic Limulus heart, James R. Groome, Mark A. Townley, and Winsor H. Watson III
A Graphical Method for Determining the Ideality of a Sedimenting Boundary, David B. Hayes and Thomas M. Laue
An On-line Interferometer for the XL-A Ultracentrifuge, Thomas M. Laue, Arthur L. Anderson, and Phillip D. Demaine
The Self-Association of Biglycan from Bovine Articular Cartilage, Jun Liu, Thomas M. Laue, Haing U. Choi, and Lawrence Rosenberg