The Department of Molecular, Cellular and Biomedical Sciences provides an education based on research and scientific information, intended to meet the needs of those interested in the biomedical and molecular/cellular life sciences.
Faculty may submit research here.
Submissions from 2014
Draft Genome Sequence of Photorhabdus temperata Strain Meg1, an Entomopathogenic Bacterium Isolated from Heterorhabditis megidis Nematodes, Sheldon G. Hurst IV, Shimaa M. Ghazal, Krystalynne Morris, Feseha Abebe-Akele, Feseha Abebe-Akele, W. Kelley Thomas, Usama M. Badr, Mona A. Hussein, Mohamed A. AbouZaied, Kamal M. Khalil, and Louis S. Tisa
Draft Genome Sequence of Frankia sp. Strain Thr, a Nitrogen-Fixing Actinobacterium Isolated from the Root Nodules of Casuarina cunninghamiana Grown in Egypt, Sheldon G. Hurst IV, Rediet Oshone, Faten Ghodhbane-Gtari, Krystalynne Morris, Feseha Abebe-Akele, W. Kelley Thomas, Amir Ktari, Karima Salem, Samira R. Mansour, Maher Gtari, and Louis S. Tisa
On the optimal trimming of high-throughput mRNA sequence data, Matthew D. MacManes
Characterization of the transcriptome, nucleotide sequence polymorphism, and natural selection in the desert adapted mouse Peromyscus eremicus, Matthew D. MacManes and Michael B. Eisen
Draft Genome Sequence of Frankia sp. Strain CcI6, a Salt-Tolerant Nitrogen-Fixing Actinobacterium Isolated from the Root Nodule of Casuarina cunninghamiana, Samira R. Mansour, Rediet Oshone, Sheldon G. Hurst IV, Krystalynne Morris, W. Kelley Thomas, and Louis S. Tisa
The Family Frankiaceae, Philippe Normand, David R. Benson, Alison M. Berry, and Louis S. Tisa
Genetic disruption of the core circadian clock impairs hippocampus-dependent memory, Sarah M. Wardlaw, Trongha X. Phan, Amit Saraf, Xuanmao Chen, and Daniel R. Storm
Molecular architecture of photoreceptor phosphodiesterase elucidated by chemical cross-linking and integrative modeling., Xiaohui Zeng-Elmore, Xiong-Zhou Gao, Ricardo Pellarin, Dina Schneidman-Duhovny, Xiu-Jun Zhang, Katie A. Kozacka, Yang Tang, Andrej Sali, Robert Chalkley, Rick H. Cote, and Feixia Chu
Only a subset of the PAB1-mRNP proteome is present in mRNA translation complexes, Chongxu Zhang, Xin Wang, Shiwha Park, Yueh-chin Chiang, Wen Xi, Thomas M. Laue, and Clyde L. Denis
Submissions from 2013
Characterization of haemoglobin from Actinorhizal plants – An in silico approach, Sanghati Bhattacharya, Arnab Sen, Subarna Thakur, and Louis S. Tisa
Electroolfactogram (EOG) Recording in the Mouse Main Olfactory Epithelium, Xuanmao Chen, Zhengui Xia, and Daniel R. Storm
Draft Genome Sequence of Frankia sp. Strain CN3, an Atypical, Noninfective (Nod–) Ineffective (Fix–) Isolate from Coriaria nepalensis, Faten Ghodhbane-Gtari, Nicholas J. Beauchemin, David Bruce, Patrick Chain, Amy Chen, Karen Walston Davenport, Shweta Deshpande, Chris Detter, Teal Furnholm, Lynne Goodwin, Maher Gtari, Cliff Han, James Han, Marcel Huntemann, Natalia Ivanova, Nikos Kyrpides, Miriam L. Land, Victor Markowitz, Kostas Mavrommatis, Matt Nolan, Imen Nouioui, Ioanna Pagani, Amrita Pati, Sam Pitluck, Catarina L. Santos, Arnab Sen, Saubashya Sur, Ernest Szeto, and Louis S. Tisa
Diversity of Frankia Strains, Actinobacterial Symbionts of Actinorhizal Plants, Maher Gtari, Louis S. Tisa, and Philippe Normand
Alteration of the exopolysaccharide production and the transcriptional profile of free-living Frankia strain CcI3 under nitrogen-fixing conditions, Hae-In Lee, Andrew J. Donati, Dittmar Hahn, Louis S. Tisa, and Woo-Suk Chang
Draft Genome Sequence of Frankia sp. Strain BMG5.12, a Nitrogen-Fixing Actinobacterium Isolated from Tunisian Soils, Imen Nouioui, Nicholas J. Beauchemin, Michael N. Cantor, Amy Chen, J. Chris Detter, Teal Furnholm, Faten Ghodhbane-Gtari, Lynne Goodwin, Mahar Gtari, Cliff Han, James Han, Marcel Huntemann, Susan Xinyu Hua, Natalia Ivanova, Nikos Kyrpides, Victor Markowitz, Kostas Mavrommatis, Natalia Mikhailova, Henrik P. Nordberg, Galina Ovchinnikova, Ioanna Pagani, Amrita Pati, Arnab Sen, Saubashya Sur, Ernest Szeto, Subarna Thakur, Luis Wall, Chia-Lin Wei, and Louis S. Tisa
Effect of salt stress on the physiology of Frankia sp strain CcI6, Rediet Oshone, Samira R. Mansour, and Louis S. Tisa
Friend or foe? A review of the mechanisms that drive Serratia towards diverse lifestyles, Lauren M. Petersen and Louis S. Tisa
Draft Genome Sequence of Frankia sp. Strain QA3, a Nitrogen-Fixing Actinobacterium Isolated from the Root Nodule of Alnus nitida, Arnab Sen, Nicholas J. Beauchemin, David Bruce, Patrick Chain, Amy Chen, Karen Walston Davenport, Shweta Deshpande, Chris Detter, Teal Furnholm, Lynne Goodwin, Maher Gtari, Cliff Han, James Han, Marcel Huntemann, Natalia Ivanova, Nikos Kyrpides, Miriam L. Land, Victor Markowitz, Kostas Mavrommatis, Matt Nolan, Imen Nouioui, Ioanna Pagani, Amrita Pati, Sam Pitluck, Catarina L. Santos, Saubashya Sur, Ernest Szeto, Fernando Tavares, and Louis S. Tisa
Characterization of pseudogenes in members of the order Frankineae, Saubashya Sur, Sangita Saha, Louis S. Tisa, Asim K. Bothra, and Arnab Sen
Contrasted evolutionary constraints on secreted and non-secreted proteomes of selected Actinobacteria, Subarna Thakur, Philippe Normand, Vincent Daubin, Louis S. Tisa, and Arnab Sen
What stories can the Frankia genomes start to tell us?, Louis S. Tisa, Nicholas J. Beauchemin, Maher Gtari, Arnab Sen, and Luis G. Wall
Phylogenetic affinities of Phobetinus to other pirate spider genera (Araneae: Mimetidae) as indicated by spinning field morphology, Mark A. Townley, Danilo Harms, and Suresh P. Benjamin
Aggregate silk gland secretions of araneoid spiders, Mark A. Townley and Edward K. Tillinghast
Draft Genome Sequence of Frankia sp. Strain BCU110501, a Nitrogen-Fixing Actinobacterium Isolated from Nodules of Discaria trinevis, Luis G. Wall, Nicholas J. Beauchemin, Michael N. Cantor, Eugenia Chaia, Amy Chen, J. Chris Detter, Teal Furnholm, Faten Ghodhbane-Gtari, Lynne Goodwin, Mahar Gtari, Cliff Han, James Han, Marcel Huntemann, Susan Xinyu Hua, Natalia Ivanova, Nikos Kyrpides, Victor Markowitz, Kostas Mavrommatis, Natalia Mikhailova, Henrik P. Nordberg, Imen Nouioui, Galina Ovchinnikova, Ioanna Pagani, Amrita Pati, Arnab Sen, Saubashya Sur, Ernest Szeto, Subarna Thakur, and Louis S. Tisa
Isoflurane regulates atypical type-A gamma-aminobutyric acid receptors in alveolar type II epithelial cells, Yun-Yan Xiang, Xuanmao Chen, Jingxin Li, Shuanglian Wang, Gil Faclier, John F. MacDonald, James C. Hogg, Beverley A. Orser, and Wei-Yang Lu
Submissions from 2012
Casuarina Root Exudates Alter the Physiology, Surface Properties, and Plant Infectivity of Frankia sp. Strain CcI3, Nicholas J. Beauchemin, Teal Furnholm, Julien Lavenus, Sergio Svistoonoff, Patrick Doumas, Didier Bogusz, Laurent Laplaze, and Louis S. Tisa
Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase, Xuanmao Chen, Zhengui Xia, and Daniel R. Storm
Estrous cycle-dependent changes of Fas expression in the bovine corpus luteum: influence of keratin 8/18 intermediate filaments and cytokines, Alice Duncan, Jennifer Forcina, Alyssa Birt, and David H. Townson
Development of a semi-high-throughput growth assay for the filamentous actinobacteria Frankia, Teal Furnholm, Nicholas J. Beauchemin, and Louis S. Tisa
The consequences of denoising marker-based metagenomic data, John M. Gaspar and W. K. Thomas
Effect of PEGylation on protein hydrodynamics, Yatin R. Gokarn, Matthew McLean, and Thomas M. Laue
Detection of high molecular weight amyloid protein complexes in patient sera using Biological On-Line Tracer Sedimentation (BOLTS), Jonathan S. Kingsbury, Thomas M. Laue, Susan F. Chase, and Lawreen H. Connors
In silico analysis reveals the role of horizontally transferred genes (HGTs) in shaping the pathogenicity of Xanthomonas, Shrabanti Kundu, Asim Bothra, Louis S. Tisa, and Arnab Sen
Proximity energies: a framework for understanding concentrated solutions, Thomas M. Laue
Differential Temperature Dependent Multimeric Assemblies of Replication and Repair Polymerases on DNA Increase Processivity, Hsiang-Kai Lin, Susan F. Chase, Thomas M. Laue, Linda Jen-Jacobson, and Michael A. Trakselis
Influence of Temperature on the Physiology and Virulence of the Insect Pathogen Serratia sp. Strain SCBI, Lauren M. Petersen and Louis S. Tisa
Identification of TTA codon containing genes in Frankia and exploration of the role of tRNA in regulating these genes, Arnab Sen, Subarna Thakur, Asim K. Bothra, Saubashya Sur, and Louis S. Tisa
Use of the novel technique of analytical ultracentrifugation with fluorescence detection system identifies a 77S monosomal translation complex, Xin Wang, Chongxu Zhang, Yueh-Chin Chiang, Shaun Toomey, Matthew P. Power, Mitchell E. Granoff, Roy Richardson, Wen Xi, Darren J. Lee, Susan F. Chase, Thomas M. Laue, and Clyde L. Denis
The Influence of Charge Distribution on Self-association and Viscosity Behavior of Monoclonal Antibody Solutions, Sandeep Yadav, Thomas M. Laue, Devendra S. Kalonia, Shubhadra N. Singh, and Steven J. Shire
Functional mapping of interacting regions of the photoreceptor phosphodiesterase (PDE6) γ-subunit with PDE6 catalytic dimer, transducin, and regulator of G-protein signaling9-1 (RGS9-1), Xiu-Jun Zhang, Xiong-Zhuo Gao, Wei Yao, and Rick H. Cote
Analysis of high-affinity assembly for AMPA receptor amino-terminal domains, Huaying Zhao, Anthony J. Berger, Patrick H. Brown, Janesh Kumar, Andrea Balbo, Carrie A. May, Ernesto Casillas Jr., Thomas M. Laue, George H. Patterson, Mark L. Mayer, and Peter Schuck
Submissions from 2011
Characterizing a novel entomopathogenic partnership between Serratia spp. and Rhabditid nematodes, Feseha Abebe-Akele, Louis S. Tisa, Eyualem Abebe, Vaughn S. Cooper, and W. Kelley Thomas
An insect pathogenic symbiosis between a Caenorhabditis and Serratia , Eyualem Abebe, Feseha-Abebe Akele, Julie Morrison, Vaughn S. Cooper, and W. Kelley Thomas
Non-Native Aggregation of an IgG1 Antibody in Acidic Conditions: 1. Unfolding, Colloidal Interactions, and Formation of Amyloid-Like High Molecular Weight Aggregates, Rebecca K. Brummitt, Douglas P. Nesta, Liuquan Chang, Susan F. Chase, Thomas M. Laue, and Christopher J. Roberts
Phosphodiesterase 6C, cGMP-specific cone alpha', Karyn B. Cahill and Rick H. Cote
An anti-coagulation agent Futhan preferentially targets GABA(A) receptors in lungepithelia: implication in treating asthma, Xuanmao Chen, Minghua Li, Zhi-Gang Xiong, Beverley A. Orser, John F. MacDonald, and Wei-Yang Lu
Functional modifications of acid-sensing ion channels by ligand-gated chloride channels, Xuanmao Chen, Paul Whissell, Beverley A. Orser, and John F. MacDonald
Phosphodiesterase 6D, cGMP-specific rod delta, Hannah J. Gitschier and Rick H. Cote
Effective charge measurements reveal selective and preferential accumulation of anions, but not cations, at the protein surface, Yatin R. Gokarn, R. Matthew Fesinmeyer, Atul Saluja, Vladimir Razinkov, Susan F. Chase, Thomas M. Laue, and David N. Brems
Fluorescence-Detected Sedimentation in Dilute and Highly Concentrated Solutions, Jonathan S. Kingsbury and Thomas M. Laue
A postreductionist framework for protein biochemistry, Thomas M. Laue and Borries Demeler
Multiple Conformations of the Cytidine Repressor DNA-Binding Domain Coalesce to One Upon Recognition of a Specific DNA Surface, Colleen L. Moody, Vira Tretyachenko-Ladokhina, Thomas M. Laue, Donald F. Senear, and Melanie J. Cocco
Phylogeny of members of the Frankia genus based on gyrB, nifH and glnII sequences, Imen Nouioui, Faten Ghodhbane-Gtari, Nicholas J. Beauchemin, Louis S. Tisa, and Maher Gtari
Shifting patterns of natural variation in the nuclear genome of caenorhabditis elegans, Eleanne Solorzano, Kazufusa Okamoto, Pushpa Datla, Way Sung, R. D. Bergeron, and W. Kelley Thomas
Significant Natural Product Biosynthetic Potential of Actinorhizal Symbionts of the Genus Frankia, as Revealed by Comparative Genomic and Proteomic Analyses, Daniel W. Udwary, Erin A. Gontang, Adam C. Jones, Carla S. Jones, Andrew W. Schultz, Jaclyn M. Winter, Jane Y. Yang, Nicholas J. Beauchemin, Todd L. Capson, Benjamin R. Clark, Eduardo Esquenazi, Alessandra S. Eustaquio, Kelle Freel, Lena Gerwick, William H. Gerwick, David Gonzalez, Wei-Ting Liu, Karla L. Malloy, Katherine N. Maloney, Markus Nett, Joshawna K. Nunnery, Kevin Penn, Alejandra Prieto-Davo, Thomas L. Simmons, Sara Weitz, Micheal C. Wilson, Louis S. Tisa, Pieter C. Dorrestein, and Bradley S. Moore
Phosphodiesterase 6H, cone-specific inhibitor, Xiu-Jun Zhang and Rick H. Cote
Submissions from 2010
Detection of poliovirus by ICC/qPCR in concentrated water samples has greater sensitivity and is less costly using BGM cells in suspension as compared to monolayers, Helene B. Balkin and Aaron B. Margolin
The modulation of TRPM7 currents by nafamostat mesilate depends directly upon extracellular concentrations of divalent cations, Xuanmao Chen, Tomohiro Numata, Minghua Li, Yasuo Mori, Beverley A. Orser, Michael F. Jackson, Zhi-Gang Xiong, and John F. MacDonald
Design and screening of ASIC inhibitors based on aromatic diamidines for combating neurological disorders, Xuanmao Chen, Beverley A. Orser, and John F. MacDonald
Diarylamidines: high potency inhibitors of acid-sensing ion channels, Xuanmao Chen, Liyan Qiu, Minghua Li, Stefan Grunder, Beverley A. Orser, Zhi-Gang Xiong, and John F. MacDonald
Why genes evolve faster on secondary chromosomes in bacteria, Vaughn S. Cooper, Samuel H. Vohr, Sarah C. Wrocklage, and Philip J. Hatcher
Function and regulation of photoreceptor phosphodiesterase (PDE6) in the visual signaling pathway., Rick H. Cote and Karyn B. Cahill
Experimental adaptation of Burkholderia cenocepacia to onion medium reduces host range, Crystal N. Ellis and Vaughn S. Cooper
Evolutionary rates and gene dispensability associate with replication timing in the Archaeon Sulfolobus islandicus, Kenneth M. Flynn, Samuel H. Vohr, Philip J. Hatcher, and Vaughn S. Cooper
Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a, Stefan Grunder and Xuanmao Chen
Short communication: Rapid antibiotic screening tests detect antibiotic residues in powdered milk products, J. Kneebone, Paul C.W. Tsang, and D. H. Townson
Applications of Sedimentation Velocity Analytical Ultracentrifugation, Thomas M. Laue
Sedimentation, Thomas M. Laue
The sedimentation properties of ferritins. New insights and analysis of methods of nanoparticle preparation, Carrie A. May, John K. Grady, Thomas M. Laue, Maura Poli, Paolo Arosio, and N. Dennis Chasteen
Auxin Carriers Localization Drives Auxin Accumulation in Plant Cells Infected by Frankia in Casuarina glauca Actinorhizal Nodules, Fancine Perrine-Walker, Patrick Doumas, Mikael Lucas, Virginie Vaissayre, Nicholas J. Beauchemin, Leah R. Band, Jerome Chopard, Amandine Crabos, Genevieve Conejero, Benjamin Peret, John R. King, Jean-Luc Verdeil, Valerie Hocher, Claudine Franche, Malcolm J. Bennett, Louis S. Tisa, and Laurent Laplaze
Ecological succession in long-term experimentally evolved biofilms produces synergistic communities, Steffen R. Poltak and Vaughn S. Cooper
Breaking the language barrier: experimental evolution of non-native Vibrio fischeri in squid tailors luminescence to the host, Brian M. Schuster, Lauren A. Perry, Vaughn S. Cooper, and Cheryl A. Whistler
Cytokeratin 18 expression inhibits Cytokine-induced death of cervical cancer cells, Brian T. Sullivan, Jessica A. Cherry, Hideo Sakamoto, Luiz E. Henkes, David H. Townson, and Bo R. Rueda
Simple sequence repeat variation in the Daphnia pulex genome, Way Sung, Abraham Tucker, R. Daniel Bergeron, Michael Lynch, and W. Kelley Thomas
Homology modeling of nitrogenase iron proteins from three Frankia strains, Saubashya Sur, Arnab Sen, Louis S. Tisa, Asim Bothra, Subarna Thakur, and Uttam Mondal
Pressure Enhanced Processes (PrEP) Enabling High Quality Two-Dimensional Gel Electrophoresis of Frankia Mycelia and Vesicle Structures, Louis S. Tisa, G. Smejkal, and W. Kuo
Expression and distribution of cytokeratin 8/18 intermediate filaments in bovine antral follicles and corpus luteum: An intrinsic mechanism of resistance to apoptosis? RID E-3660-2010, David H. Townson, Amanda N. Putnam, Brian T. Sullivan, Linkai Guo, and Helen F. Irving-Rodgers
Submissions from 2009
Insertion sequence content reflects genome plasticity in strains of the root nodule actinobacterium Frankia, Derek M. Bickhart, Johann P. Gogarten, Pascal Lapierre, Louis S. Tisa, Philippe Normand, and David R. Benson
Dodge this: do environmental chemicals impact your health?, Gale B. Carey
The Open AUC Project, Helmut Colfen, Thomas M. Laue, Wendel Wohlleben, Kristian Schilling, Engin Karabudak, Bradley W. Langhorst, Emre Brookes, Bruce Dubbs, Dan Zollars, Mattia Rocco, and Borries Demeler
Susceptibility of Caenorhabditis elegans to Burkholderia infection depends on prior diet and secreted bacterial attractants, Vaughn S. Cooper, Wendy A. Carlson, and John J. LiPuma
War of the worlds: our worlds are colliding and infectious disease is winning - emerging diseases and the one health initiative, Richard French
NUTS and BOLTS: Applications of fluorescence-detected sedimentation, Rachel R. Kroe and Thomas M. Laue
Construction and purification of His-tagged staphylococcal ArsB protein, an integral membrane protein that is involved in arsenical salt resistance, Carmela Mascio, Donald J. White, and Louis S. Tisa
Methods for Measuring Size, Molecular Weight and Presence of Subunits, David G. Rhodes, R. E. Bossio, and Thomas M. Laue
Determination of Protein Purity, David G. Rhodes and Thomas M. Laue
Developmental changes in spider spinning fields: a comparison between Mimetus and Araneus (Araneae: Mimetidae, Araneidae), Mark A. Townley and Edward K. Tillinghast
The zinc finger protein Zn72D and DEAD box helicase Belle interact and control maleless mRNA and protein levels, Kathleen A. Worringer, Feixia Chu, and Barbara Panning
Submissions from 2008
Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons, Michael A. Beazely, Aeni Lim, Hongbin Li, Catherine Trepanier, Xuanmao Chen, Bikram Sidhu, and John F. MacDonald
Cutting Edge Structural Protein from the Jaws of Nereis virens, Chris C. Broomell, Susan F. Chase, Thomas M. Laue, and J. Herbert Waite
Microvascular endothelial cells of the bovine corpus luteum: A comparative examination of the estrous cycle and pregnancy, Jessica Ann Cherry, Xiaoying Hou, Bo Ruben Rueda, John Stewart Davis, and David Harrison Townson
Analytical Ultracentrifugation: Sedimentation Velocity and Sedimentation Equilibrium, James L. Cole, Jeffrey W. Lary, Thomas P. Moody, and Thomas M. Laue
The cGMP signaling pathway in retinal photoreceptors and the central role of photoreceptor phosphodiesterase (PDE6)., Rick H. Cote
The Modulation Of Transthyretin Tetramer Stability By Cysteine-10 Adducts And The Drug Diflunisal: Direct Analysis By Fluorescence-detected Analytical Ultracentrifugation, Jonathan S. Kingsbury, Thomas M. Laue, Elena S. Klimtchuk, Roger Theberge, Catherine E. Costello, and Lawreen H. Connors
Comparative secretome analysis suggests low plant cell wall degrading capacity in Frankia symbionts, Juliana E. Mastronunzio, Louis S. Tisa, Philippe Normand, and David R. Benson
Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a, Martin Paukert, Xuanmao Chen, Georg Polleichtner, Hermann Schindelin, and Stefan Grunder
On the nature of fur evolution: A phylogenetic approach in Actinobacteria, Catarina L. Santos, João Viera, Fernando Tavares, David R. Benson, Louis S. Tisa, Alison M. Berry, Pedro Moradas-Ferreira, and Philippe Normand
The implication of life style on codon usage patterns and predicted highly expressed genes for three Frankia genomes, Arnab Sen, Saubashya Sur, Asim K. Bothra, David R. Benson, Philippe Normand, and Louis S. Tisa
Bioinformatic Analysis of Codon Usage Patterns in a Free Living Diazotroph, Azotobacter vinelandii, Saubashya Sur, Malay Bhattacharya, Asim K. Bothra, Louis S. Tisa, and Arnab Sen
In silico Analysis of Chlorobium Genomes Divulge Insights into the Lifestyle of the Bacteria, Saubashya Sur, Asim K. Bothra, Manprit Bajwa, Louis S. Tisa, and Arnab Sen