Honors Theses and Capstones
Date Completed
Spring 2023
Abstract
A quantitative, voxel-wise meta-analysis was performed to investigate the brain regions involved in healthy human swallowing. Studies included in the meta-analysis (1) examined water swallowing, saliva swallowing, or both, (2) included healthy, normal subjects, and (3) reported stereotaxic brain activation coordinates in standard space. Following these criteria, a systematic literature review identified 8 studies that met the criteria. An activation likelihood estimation (ALE) meta-analysis and meta-analytic connectivity modelling (MACM) analysis were performed with BrainMap software. Ten clusters with high activation likelihood were found in the bilateral precentral gyri, right insula, left declive, right medial frontal gyrus, right dorsal nucleus of the thalamus, and the bilateral dentate nuclei of the cerebellum. Meta-analytic connectivity modelling revealed functional two-way and one-way connections between the regions, forming an interconnected network. Together, these finding indicate an extensive swallowing network made up of the key activated regions and the associated areas within those regions.
First Advisor
Donald A. Robin
Second Advisor
Keri Miloro
College or School
COLSA
Department or Program
Neuroscience and Behavior
Degree Name
Bachelor of Science
Recommended Citation
Tilton, Chris R., "Meta-Analytic Connectivity Modelling of Healthy Swallowing" (2023). Honors Theses and Capstones. 703.
https://scholars.unh.edu/honors/703
Included in
Behavioral Neurobiology Commons, Biomechanics Commons, Biomedical Informatics Commons, Other Neuroscience and Neurobiology Commons, Other Public Health Commons, Systems Neuroscience Commons