Defeating Cytoplasmic Sequestration of p53 in Human Breast Cancer Cells; Is Mortalin Involved?

Authors

• Sarah Yunes, University of New Hampshire - Main Campus

Date Completed

Spring 2012

Abstract

Cytoplasmic sequestration of p53, possibly caused by p53 interacting with mortalin, can prevent p53 from functioning in DNA repair and apoptosis, causing aberrant growth. This project treated SKBR3 breast cancer cells with MKT-077, a dye that is a competitive binder to mortalin to see if it would result in the release of p53 from the cytoplasm and restoration of p53 function. Treatment resulted in partial translocation of a protein suspected to be p53 to the nucleus and apoptosis initiated at the mitochondria.

First Advisor

Charles Walker

College or School

COLSA

Department or Program

Biochemistry, Molecular and Cellular Biology

Recommended Citation

Yunes, Sarah, "Defeating Cytoplasmic Sequestration of p53 in Human Breast Cancer Cells; Is Mortalin Involved?" (2012). Honors Theses and Capstones. 81.
https://scholars.unh.edu/honors/81