Honors Theses and Capstones

Date of Award

Spring 2023

Project Type

Senior Honors Thesis

College or School

COLSA

Department

Molecular, Cellular, and Biomedical Sciences

Program or Major

Biochemistry, Molecular and Cellular Biology

Degree Name

Bachelor of Science

First Advisor

Sarah Walker

Abstract

Ovarian cancer has a survival rate of 50 percent just five years after being diagnosed (Nguyen et al. 2020). Finding new ways to treat ovarian cancer is important to increase the survival of patients who have been diagnosed. BCL6 is a transcription factor that is involved with metastasis and promoting chemotherapy resistant cancer cells. Finding a way to inhibit BCL6 could help prevent the things listed above and lead to a new treatment for patients with ovarian cancer. Researching genes that BCL6 regulates may offer new insights into treatments that can be researched to see if they are effective in inhibiting BCL6, which was the focus of my research. Using bioinformatics and cell culturing I researched drugs that had the possibility of inhibiting BCL6 and tested their effectiveness against ovarian cancer cell lines.

Download

Share

COinS