Using RNA Sequencing to Examine the Dehydration Response in the Hypothalamus and Pituitary Gland of a Desert-Adapted Mouse

Author

Sarah A. Nicholls, University of New Hampshire - Main CampusFollow
Sarah M. Couture, University of New Hampshire - Main CampusFollow
Danielle M. Blumstein, University of New Hampshire - Main CampusFollow
Matthew D. MacManes, University of New Hampshire - Main CampusFollow

Date

4-2024

Project Type

URC Presentation

Department

Molecular, Cellular, and Biomedical Sciences

College or School

COLSA

Class Year

Junior

Major

Biochemistry, Molecular and Cellular Biology

Faculty Research Advisor

Matthew MacManes

Language

English

Abstract

The exact mechanisms by which desert-adapted animals avoid dehydration-induced complications are unknown, though there are likely ties to the general mammalian dehydration response, a multi-system process spearheaded by the brain. Peromyscus eremicus, the cactus mouse, can survive its whole life without intaking water and is commonly used as a model to study desert adaptations. Using bulk RNA sequencing, we identified patterns of differential gene expression in dehydrated vs. hydrated cactus mice, opening doors for future molecular studies into the dehydration response.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

Recommended Citation

Nicholls, Sarah A.; Couture, Sarah M.; Blumstein, Danielle M.; and MacManes, Matthew D., "Using RNA Sequencing to Examine the Dehydration Response in the Hypothalamus and Pituitary Gland of a Desert-Adapted Mouse" (2024). Undergraduate Research Conference (URC) Student Presentations. 604.
https://scholars.unh.edu/urc/604