Date
4-2019
Project Type
URC Presentation
Department
Department of Chemical Engineering
College or School
CEPS, COLSA
Class Year
Sophomore, Junior
Major
Bioengineering, Biochemistry
Faculty Research Advisor
Kyung Jae Jeong
Abstract
We have previously made a mechanically tough hydrogel by creating an interpenetrating network (IPN) of gelatin and silk fibroin. The resulting hydrogel exhibited a very high stiffness (~2 MPa) and excellent biofunctionality, promoting cell adhesion and proliferation on its surface. However, inducing cellular growth inside the hydrogel was challenging. Here, we introduce a new method of creating an injectable gelatin-silk fibroin IPN hydrogel which can be used to encapsulate mammalian cells inside the hydrogel. Results from a confocal microscope imaging supports cell proliferation on all layers of the hydrogel. Gelatin-silk IPN hydrogel resulted in higher cellular proliferation than the gelatin only hydrogel. This makes for a great asset in tissue engineering and regenerative medicine.
Recommended Citation
Boudreau, Ryann D.; Yee, Rachel A.; and Jeong, Kyung Jae, "Silk-Gelatin Composite Hydrogels for Tissue Engineering" (2019). Undergraduate Research Conference (URC) Student Presentations. 450.
https://scholars.unh.edu/urc/450