Date of Award

Winter 2010

Project Type

Thesis

Program or Major

Chemistry

Degree Name

Master of Science

First Advisor

Edward H Wong

Second Advisor

Gary R Weisman

Abstract

Pendant-armed cyclic polyamines have been demonstrated to be promising ligands for the development of new metal-based radiopharmaceuticals for positron-emission tomography (PET). Macrocyclic polyamines bearing pendant arms can effectively bind specific metals with suitable complexation kinetics and stability while attached to a tumor-targeting vector or peptide. 64Cu-radiolabeled peptides containing the chelator 1,4,7-triazacyclononane 1,4,7-triacetate have been shown to possess superior properties which overcome commonly observed problems such as demetallation and accumulation of the radio-metal in non-targeted tissues. To model these radiolabeled bioconjugates and to gain insight into this observed bio-stability, the synthesis of a copper (II) complex of a new triazacyclononane derivative containing one amide and two acetate groups (NOAM2A) has been performed. Studies of its acid inertness and electrochemistry behavior have been investigated. Complementary, copper (II) complexes of other triazacyclononane intermediates have also been explored.

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