Date of Award

Fall 2006

Project Type

Thesis

Program or Major

Chemistry

Degree Name

Master of Science

First Advisor

Edward H Wong

Abstract

The use of radiometal-based radiopharmaceuticals for the therapy and diagnostic imaging of various diseases is rapidly increasing. Metal complex stability in vivo is an important factor to keep the metal chelate intact under physiological conditions for the radiopharmaceutical application. A novel class of cross-bridged tetraazamacrocycles with nonadjacent nitrogens bridged by an ethylene unit was developed to make metal complexes with good thermodynamic stability and higher kinetic inertness towards dissociation. Complexes of Ga(III) and In(III) radionuclides are widely used in diagnostic imaging and their respective half-lives are convenient for specific diseases. The new complexes [In-CB-DO2A]+ and [In-CB-TE2A]+ have been prepared by direct and indirect routes respectively. In addition, to predict how these complexes will survive in vivo, their decomplexation half-lives under forcing conditions are used as first indicators. Related diamagnetic Ga3+, In3+, Zn2+ , Cd2+, and Hg2+ complexes were also included for these acid decomplexation studies by NMR spectroscopy in DCl/D 2O solution. In general, relative inertness can be correlated to their solid-state structures.

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