Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Abstract
This review focuses on recent advances in non-enzymatic electrochemical biosensors for detection of hydrophobic metabolites. Electrochemical approaches have been widely applied in many established and emerging technologies and a large range of electrochemical biosensors have been used for detection of various hydrophobic metabolites. Despite the progress made in this field, some problems still exist, specifically, electrochemical detection of hydrophobic biomarkers can be challenging in complex biological fluids. In this review, we have highlighted some of the most representative surface modification technologies that have been employed in electrochemical biosensors to counter the problems of poor sensitivity and selectivity towards hydrophobic metabolites. The hydrophobic metabolites discussed in this review include uric acid, epinephrine, cortisol, cholesterol, tyrosine, adenine, guanine, cytosine, and thymine. This is followed by discussion on future research directions for electrochemical sensing of hydrophobic biomarkers.
Publication Date
11-1-2021
Publisher
Elsevier
Journal Title
Sensors and Actuators Reports
Digital Object Identifier (DOI)
Document Type
Article
Recommended Citation
Zahra Panahi, Luciana Custer, Jeffrey Mark Halpern, Recent advances in non-enzymatic electrochemical detection of hydrophobic metabolites in biofluids, Sensors and Actuators Reports, Volume 3, 2021, 100051, ISSN 2666-0539, https://doi.org/10.1016/j.snr.2021.100051.
Comments
This is an Open Access article published by Elsevier in Sensors and Actuators Reports in 2021, available online: https://dx.doi.org/10.1016/j.snr.2021.100051