Role of Mutations in Differential Recognition of Viral RNA Molecules by Peptides
Abstract
The conserved noncoding RNA elements in viral genomes interact with proteins to regulate various events during viral replication. We report studies on the recognition mechanisms of two helical peptides, namely, a native (Rev) peptide and a lab-evolved (RSG1.2) peptide, by a highly conserved viral RNA element from the human immunodeficiency virus 1 genome. Specifically, we investigated the physical interactions between the viral RNA molecule and helical peptides by computing free energy changes on mutating key amino acid residues involved in recognition of an internal loop in the viral RNA molecule.
Publication Date
7-14-2022
Publisher
ACS Publications
Journal Title
Journal of Chemical Information and Modeling
Digital Object Identifier (DOI)
Document Type
Article
Recommended Citation
Amit Kumar and Harish Vashisth. Role of Mutations in Differential Recognition of Viral RNA Molecules by Peptides, Journal of Chemical Information and Modeling 2022 62 (14), 3381-3390, DOI: 10.1021/acs.jcim.2c00376
Rights
Copyright © 2022 American Chemical Society