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Abstract
The type 3 adenylyl cyclase (AC3) is localized to olfactory cilia in the main olfactory epithelium (MOE) and primary cilia in the adult mouse brain. Although AC3 has been strongly implicated in odor perception and olfactory sensory neuron (OSN) targeting, its role in granule cells (GCs), the most abundant interneurons in the main olfactory bulb (MOB), remains largely unknown. Here, we report that the deletion of AC3 leads to a significant reduction in the size of the MOB as well as the level of adult neurogenesis. The cell proliferation and cell cycle in the subventricular zone (SVZ), however, are not suppressed in AC3−/− mice. Furthermore, AC3 deletion elevates the apoptosis of GCs and disrupts the maturation of newly formed GCs. Collectively, our results identify a fundamental role for AC3 in the development of adult-born GCs in the MOB.
Department
Molecular, Cellular and Biomedical Sciences
Publication Date
5-25-2015
Journal Title
PLOS One
Publisher
PLOS
Digital Object Identifier (DOI)
Document Type
Article
Recommended Citation
Luo J, Chen X, Pan YW, Lu S, Xia Z, Storm DR. The type 3 adenylyl cyclase is required for the survival and maturation of newly generated granule cells in the olfactory bulb. PloS one. 2015;10(3):e0122057. doi: 10.1371/journal.pone.0122057. PubMed PMID: 25807252; PubMed Central PMCID: PMC4373939.
Rights
© 2015 Luo et al.
Comments
This is an article published by PLOS in PLOS One in 2015, available online: https://dx.doi.org/10.1371/journal.pone.0122057