A plasmid-encoded anion-translocating ATPase
Abstract
An anion-translocating ATPase has been identified as the product of the arsenical resistance operon of resistance plasmid R773. When expressed in Escherichia coli this ATP-driven oxyanion pump catalyzes extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit enzyme produces resistance to arsenite and antimonite. A third gene, arsC, expands the substrate specificity to allow for arsenate pumping and resistance.
Department
Molecular, Cellular and Biomedical Sciences
Publication Date
7-1-1990
Journal Title
Biochimica et Biophysica Acta (BBA) - Bioenergetics
Publisher
Elsevier
Digital Object Identifier (DOI)
Document Type
Article
Recommended Citation
Rosen, B.P., C.M. Hsu, C.E. Karkaria, P. Kaur, J.B. Owolabi, and L.S. Tisa. 1990. A plasmid-encoded anion translocating ATPase. Biochim. Biophys. Acta 1018:203-205.
Rights
© 1990 Published by Elsevier B.V.