The long-term outcomes and costs of diabetes mellitus among renal transplant recipients: Tacrolimus versus cyclosporine.
Abstract
Abstract
Anti-rejection regimens for renal transplants have changed dramatically during the past 20 years, but there are few long-term studies relating cost, mortality, or graft failure simultaneously to disease-pharmacotherapy couplets. We analyzed US Renal Data System data on a matched-pair cohort of first, single organ kidney transplants from 1998 through 2002 over up to 5 years following transplantation for patients on tacrolimus or low-dose cyclosporine, stratifying by whether the recipient had pre-existing or new onset diabetes. Kaplan-Meier survival curves show mortality and survival differences associated with diabetes, but no additional incremental effects of immune suppression regimen. Significant cost increases are reported for patients receiving tacrolimus above and beyond the extra costs associated with diabetes.
Department
Health Management and Policy
Publication Date
6-2011
Journal Title
Value in Health
Publisher
Elsevier
Digital Object Identifier (DOI)
10.1016/j.jval.2010.10.030
Document Type
Article
Recommended Citation
Woodward, R.S., Flore, M.C., Machnicki, G., Brennan, D.C. The long-term outcomes and costs of diabetes mellitus among renal transplant recipients: Tacrolimus versus cyclosporine (2011) Value in Health, 14 (4), pp. 443-449. doi: 10.1016/j.jval.2010.10.030
Rights
Copyright © 2011, International Society for Pharmacoeconomics and Outcomes Research (ISPOR).