Endothelial-Dependent Flow-Mediated Dilation in African Americans With Masked-Hypertension

Authors

• Praveen Veerabhadrappa, Temple University
• Keith M. Diaz, Temple University
• Deborah L. Feairheller, University of New Hampshire, DurhamFollow
• Kathleen M. Sturgeon, University of Pennsylvania
• Sheara T. Williamson, Temple University
• Deborah L. Crabbe, Temple University
• Abul M. Kashem, Temple University
• Michael D. Brown, Temple University

Abstract

Office-blood pressure (BP) measurements alone overlook a significant number of individuals with masked-hypertension (office-BP: 120/80–139/89mmHg and 24-h ambulatory BP monitoring (ABPM) daytime ≥135/85mmHg or night-time ≥120/70mmHg). Diminished endothelial function contributes to the pathogenesis of hypertension. To better understand the pathophysiology involved in the increased cardiovascular (CV) disease risk associated with masked-hypertension, we estimated the occurrence, assessed the endothelial function, compared plasma levels of inflammatory markers, white blood cell count (WBC count), tumor necrosis factor-α (TNF-α), and high sensitivity C-reactive protein (hsCRP) and examined the possible relationship between endothelial function and inflammatory markers in apparently healthy prehypertensive (office-BP: 120/80–139/89mmHg) African Americans.

Department

Kinesiology

Publication Date

10-1-2011

Publication Title

American Journal of Hypertension

Digital Object Identifier (DOI)

https://dx.doi.org/10.1038/ajh.2011.103

Recommended Citation

Veerabhadrappa P, Diaz KM, Kashem AM, Crabbe DL, Feairheller DL, Sturgeon KM, Williamson ST, Brown MD. Endothelial-Dependent Flow-Mediated Dilation in African Americans with Masked Hypertension. American Journal of Hypertension. 24(10), 1102-1107. 2011.

Rights

© 2011 by the American Journal of Hypertension, Ltd.