NADPH Oxidase p22phox Gene Polymorphisms and Oxidative Stress Responses to Exercise Training in Pre and Stage 1 Hypertensives

Authors

Deborah L. Feairheller, University of New Hampshire, DurhamFollow
Michael D. Brown, Temple University
Joon-Young Park, University of Maryland at College Park
Tina E. Brinkley, University of Maryland at College Park
Samar Basu, Uppsala Universitet
James M. Hagberg, University of Maryland at College Park
Robert E. Ferrell, University of Pittsburgh
Nicola M. Fenty-Stewart, Temple University

Abstract

Oxidative stress that is mediated through NADPH oxidase activity plays a role in the pathology of hypertension, and aerobic exercise training reduces NADPH oxidase activity. The involvement of genetic variation in the p22phox (CYBA) subunit genes in individual oxidative stress responses to aerobic exercise training has yet to be examined in Pre and Stage 1 hypertensives.

Department

Kinesiology

Publication Date

7-2009

Journal Title

Medicine & Science in Sports & Exercise

Publisher

Wolters Kluwer

Digital Object Identifier (DOI)

https://dx.doi.org/10.1249/MSS.0b013e318199cee8

Document Type

Article

Recommended Citation

Feairheller DL, Park JY, Ellis T, Basu S, Hagberg JM, Brown MD, Fenty-Stewart N. NADPH Oxidase p22phox Gene Polymorphisms and Oxidative Stress Responses to Exercise Training in Pre and Stage 1 Hypertensives. Medicine & Science in Sports & Exercise. 41, 1421-1428. 2009.