Zinc Carbenoid-mediated Chain Extension of β-Keto Amides

Abstract

The reaction of β-keto amides with ethyl(iodomethyl)zinc provides access to a wide variety of γ-keto amides, including primary, secondary, and tertiary amides. Although the reaction of α-substituted β-keto amides are in many cases unsatisfactory, the method can be applied to a broad spectrum of substrates that possess imide and olefinic functionality.

Department

Chemistry

Publication Date

10-15-2001

Journal Title

Tetrahedron

Publisher

Elsevier

Digital Object Identifier (DOI)

10.1016/S0040-4020(01)00879-1

Document Type

Article

Rights

Copyright © 2001, Elsevier

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