"Differential Resistance to Staphylococcus aureus Challenge in Major Hi" by Paul F. Cotter, Robert L. Taylor Jr. et al.
 

Differential Resistance to Staphylococcus aureus Challenge in Major Histocompatibility (B) Complex Congenic Lines

Abstract

Ten inbred B-congenic Leghorn lines were challenged with two isolates of Staphylococcus aureus at 3 days and 6 wk of age. Significant differences in mortality were observed among such lines when challenged at 3 days with either S. aureus Isolate P4L (moderately pathogenic) or S. aureus Isolate 3727 (highly pathogenic). Line 331 (B 2/B 2 genotype) had lower mortality than either Line 004 (B 17/B 17, χ2 = 4.13, P < .05) or Line 253 (B 18/B 18, χ2 = 4.23, P < .05) challenged with Isolate P4L. The use of a susceptibility index allowed for the detection of additional differences among the various lines challenged by Isolate 3727. Line 336 (B Q/B Q) was more resistant than either Line 335 (B 19/B 19 , P < .01) or Line 330 (B 21 /B 21, P < .01). No significant differences were found among the lines challenged at 6 wk by either isolate. The results provide additional evidence for the importance of the B complex in genetically determined disease resistance, and further demonstrate the usefulness of congenic lines in such investigations.

Publication Date

11-1992

Journal Title

Poultry Science

Publisher

Oxford journals

Digital Object Identifier (DOI)

10.3382/ps.0711873

Scientific Contribution Number

1678

Document Type

Article

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