Title

Susceptibility to spontaneous atherosclerosis in pigeons: An autosomal recessive trait

Abstract

The inheritance pattern for susceptibility to spontaneous (noninduced) aortic atherosclerosis in pigeons was determined by crossbreeding and backcrossing experiments with atherosclerosis-susceptible White Carneau and atherosclerosis-resistant Show Racer breeds. Susceptibility, assessed by the presence of grossly visible lesions at the celiac bifurcation of the aorta at 3 years of age, demonstrated an inheritance pattern consistent with an autosomal recessive Mendelian trait. Cell culture studies indicated that susceptibility is a constitutive property of aortic cells as evidenced by vacuole formation and lipid content in smooth muscle cells from various tissues in susceptible pigeons.

Publication Date

5-1-2010

Journal Title

Journal of Heredity

Publisher

Oxford University Press

Digital Object Identifier (DOI)

10.1093/jhered/92.5.439

Scientific Contribution Number

2074

Document Type

Article

Rights

© 2001 The American Genetic Association