Susceptibility to spontaneous atherosclerosis in pigeons: An autosomal recessive trait
Abstract
The inheritance pattern for susceptibility to spontaneous (noninduced) aortic atherosclerosis in pigeons was determined by crossbreeding and backcrossing experiments with atherosclerosis-susceptible White Carneau and atherosclerosis-resistant Show Racer breeds. Susceptibility, assessed by the presence of grossly visible lesions at the celiac bifurcation of the aorta at 3 years of age, demonstrated an inheritance pattern consistent with an autosomal recessive Mendelian trait. Cell culture studies indicated that susceptibility is a constitutive property of aortic cells as evidenced by vacuole formation and lipid content in smooth muscle cells from various tissues in susceptible pigeons.
Publication Date
5-1-2010
Journal Title
Journal of Heredity
Publisher
Oxford University Press
Digital Object Identifier (DOI)
10.1093/jhered/92.5.439
Scientific Contribution Number
2074
Document Type
Article
Rights
© 2001 The American Genetic Association
Recommended Citation
Smith, S. C.; Smith, E. C.; and Taylor, R. L. Jr., "Susceptibility to spontaneous atherosclerosis in pigeons: An autosomal recessive trait" (2010). Journal of Heredity. 114.
https://scholars.unh.edu/nhaes/114