Title

The long-term outcomes and costs of diabetes mellitus among renal transplant recipients: Tacrolimus versus cyclosporine.

Abstract

Abstract

Anti-rejection regimens for renal transplants have changed dramatically during the past 20 years, but there are few long-term studies relating cost, mortality, or graft failure simultaneously to disease-pharmacotherapy couplets. We analyzed US Renal Data System data on a matched-pair cohort of first, single organ kidney transplants from 1998 through 2002 over up to 5 years following transplantation for patients on tacrolimus or low-dose cyclosporine, stratifying by whether the recipient had pre-existing or new onset diabetes. Kaplan-Meier survival curves show mortality and survival differences associated with diabetes, but no additional incremental effects of immune suppression regimen. Significant cost increases are reported for patients receiving tacrolimus above and beyond the extra costs associated with diabetes.

Publication Date

6-2011

Journal Title

Value in Health

Publisher

Elsevier

Digital Object Identifier (DOI)

10.1016/j.jval.2010.10.030

Document Type

Article

Rights

Copyright © 2011, International Society for Pharmacoeconomics and Outcomes Research (ISPOR).