Title

Tandem Chain Extension-Homoenolate Formation: The Formation of α-Methylated-γ-Keto Esters

Abstract

A tandem chain extension−homoenolate formation reaction is described. The treatment of β-keto esters with the Furukawa reagent followed by exposure to a catalytic amount of trimethylsilyl chloride provides access to an ester homoenolate.

Publication Date

9-1-2001

Journal Title

Organic Letters

Publisher

American Chemical Society

Digital Object Identifier (DOI)

10.1021/ol016485t

Document Type

Article

Rights

Copyright © 2001, American Chemical Society