Date of Award
Program or Major
Master of Science
Diabetes mellitus accelerates atherogenesis, but the exact mechanisms involved are unknown. This study examined the effects of hyperglycemia on the inflammatory transcription factor peroxisome proliferator activated receptor gamma (PPARgamma), known to be involved in atherogenesis, and the ATP binding cassette A1 (ABCA1) protein that is a downstream product of PPARgamma. ABCA1 is a membrane bound transporter that is involved in reverse cholesterol transport via high density lipoprotein cholesterol (HDL-C). Hamsters were divided into two groups; hyperlipemic animals fed a high fat/high cholesterol control diet (C) and hyperlipemic/hyperglycemic animals that received the high fat diet and were administered streptozotocin. Half of the hamsters (23) in each group were sacrificed at 8 weeks and the other half at 24 weeks. (Abstract shortened by UMI.).
LaMarca, Craig, "Effects of STZ induced hyperglycemia and hyperlipemia on PPARgamma and ABCA1 in a hamster model of atherogenesis" (2006). Master's Theses and Capstones. 203.