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Three-dimensional bioprinting is a rapidly growing field attempting to recreate functional tissues for medical and pharmaceutical purposes. Development of functional tissue requires deposition of multiple biomaterials encapsulating multiple cell types i.e. bio-ink necessitating switching ability between bio-inks. Existing systems use more than one print head to achieve this complex interchangeable deposition, which decreases efficiency, structural integrity, and accuracy. In this research, we developed a nozzle system capable of switching between multiple bio-inks with continuous deposition ensuring the minimum transition distance so that precise deposition transitioning can be achieved. Finally, the effect of rheological properties of different bio-material compositions on the transition distance is investigated by fabricating the sample scaffolds.
Journal of Medical Devices
Digital Object Identifier (DOI)
Version of Record: https://dx.doi.org/10.1115/1.4055249
Nelson, Cartwright; Tuladhar, Slesha; and Habib, MD, "Designing an Interchangeable Multi-Material Nozzle System for the 3D Bioprinting Process" (2022). Journal of Medical Devices. 34.