Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase
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Cilia of olfactory sensory neurons are the primary sensory organelles for olfaction. The detection of odorants by the main olfactory epithelium (MOE) depends on coupling of odorant receptors to the type 3 adenylyl cyclase (AC3) in olfactory cilia. We monitored the effect of airflow on electro-olfactogram (EOG) responses and found that the MOE of mice can sense mechanical forces generated by airflow. The airflow-sensitive EOG response in the MOE was attenuated when cAMP was increased by odorants or by forskolin suggesting a common mechanism for airflow and odorant detection. In addition, the sensitivity to airflow was significantly impaired in the MOE from AC3−/− mice. We conclude that AC3 in the MOE is required for detecting the mechanical force of airflow, which in turn may regulate odorant perception during sniffing.
Molecular, Cellular and Biomedical Sciences
Journal of Neuroscience
Society for Neuroscience
Digital Object Identifier (DOI)
Chen X, Xia Z, Storm DR. Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012;32(45):15769-78. doi: 10.1523/JNEUROSCI.2180-12.2012. PubMed PMID: 23136416; PubMedCentralPMCID: PMC3506261.
© 2012 the authors
This is an article published by Society for Neuroscience in Journal of Neuroscience in 2012, available online: https://dx.doi.org/10.1523/JNEUROSCI.2180-12.2012