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The type 1 adenylyl cyclase (AC1) is an activity-dependent, calcium-stimulated adenylyl cyclase expressed in the nervous system that is implicated in memory formation. We examined the locomotor activity, and impulsive and social behaviors of AC1+ mice, a transgenic mouse strain overexpressing AC1 in the forebrain. Here we report that AC1+ mice exhibit hyperactive behaviors and demonstrate increased impulsivity and reduced sociability. In contrast, AC1 and AC8 double knock-out mice are hypoactive, and exhibit increased sociability and reduced impulsivity. Interestingly, the hyperactivity of AC1+ mice can be corrected by valproate, a mood-stabilizing drug. These data indicate that increased expression of AC1 in the forebrain leads to deficits in behavioral inhibition.
Molecular, Cellular and Biomedical Sciences
Journal of Neuroscience
Society for Neuroscience
Digital Object Identifier (DOI)
Chen X, Cao H, Saraf A, Zweifel LS, Storm DR. Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015;35(1):339-51. doi: 10.1523/JNEUROSCI.2478-14.2015. PubMed PMID: 25568126; PubMed CentralPMCID: PMC4287152.
© 2015 the authors