Department of Chemical Engineering
College or School
Faculty Research Advisor
Kyung Jae Jeong
We have previously made a mechanically tough hydrogel by creating an interpenetrating network (IPN) of gelatin and silk fibroin. The resulting hydrogel exhibited a very high stiffness (~2 MPa) and excellent biofunctionality, promoting cell adhesion and proliferation on its surface. However, inducing cellular growth inside the hydrogel was challenging. Here, we introduce a new method of creating an injectable gelatin-silk fibroin IPN hydrogel which can be used to encapsulate mammalian cells inside the hydrogel. Results from a confocal microscope imaging supports cell proliferation on all layers of the hydrogel. Gelatin-silk IPN hydrogel resulted in higher cellular proliferation than the gelatin only hydrogel. This makes for a great asset in tissue engineering and regenerative medicine.
Boudreau, Ryann D.; Yee, Rachel A.; and Jeong, Kyung Jae, "Silk-Gelatin Composite Hydrogels for Tissue Engineering" (2019). Undergraduate Research Conference (URC) Student Presentations. 450.