Date of Award
Program or Major
Master of Science
Radiopharmaceuticals are radioactive compounds which are used in radiotherapy or diagnosis. They have attracted a great deal of attention over the last decades for molecular imaging. Coordination chemistry also plays an important role in designing metal-based radiopharmaceuticals. A novel class of tetraazamacrocycle ligands where two non-adjacent nitrogens are bridged by an ethylene cross-bridge show good thermodynamic stability and high kinetic inertness in their metal complexes. Seven trivalent metal (Y3+, La3+, Ga3+, In3+) complexes of cross-bridged ligands have been synthesized and characterized. Two vanadyl complexes were prepared as well. All metal complexations have been investigated under microwave-assisted conditions. Both Ga-CB-TE2P and In-CB-TE2P are remarkably stable under very acidic conditions even at high temperature. X-ray crystal structures of Y-CB-TE2A and La-CB-TE2A were obtained which show that both metals are out of the cavity of the ligand and attempts to convert them into fully-engulfed complexes were unsuccessful.
Wang, Han, "Trivalent metal complexation of pendant-armed cross-bridged cyclams" (2010). Master's Theses and Capstones. 616.