Date of Award

Winter 2010

Project Type


Program or Major


Degree Name

Master of Science

First Advisor

Edward Wong


Radiopharmaceuticals are radioactive compounds which are used in radiotherapy or diagnosis. They have attracted a great deal of attention over the last decades for molecular imaging. Coordination chemistry also plays an important role in designing metal-based radiopharmaceuticals. A novel class of tetraazamacrocycle ligands where two non-adjacent nitrogens are bridged by an ethylene cross-bridge show good thermodynamic stability and high kinetic inertness in their metal complexes. Seven trivalent metal (Y3+, La3+, Ga3+, In3+) complexes of cross-bridged ligands have been synthesized and characterized. Two vanadyl complexes were prepared as well. All metal complexations have been investigated under microwave-assisted conditions. Both Ga-CB-TE2P and In-CB-TE2P are remarkably stable under very acidic conditions even at high temperature. X-ray crystal structures of Y-CB-TE2A and La-CB-TE2A were obtained which show that both metals are out of the cavity of the ligand and attempts to convert them into fully-engulfed complexes were unsuccessful.