Date of Award
Program or Major
Master of Science
Gary R Weisman
A novel synthetic methodology towards a C2-symmetric- N,N'-bis-carboxymethyl-dibenzo-annelated cross-bridged cyclam is here presented. This methodology required a disparate approach from that traditionally used to prepare N-pendant-armed derivatives of the cross-bridged cyclam and cyclen macrocycles. Essential to the success of the synthesis are new conditions for the protective alkylation, reductive ring expansion, and chemoselective deprotection of the dibenzo-annelated cross-bridged cyclam macrocycle.*.
Martin, David J., "C2-symmetric dibenzo-annelated cross-bridged cyclam: Synthesis, functionalization, and copper complexation" (2008). Master's Theses and Capstones. 426.