Date of Award
Program or Major
Communication Sciences and Disorders
Master of Science
Donald A Robin
Jenna L Campbell
Amy E Ramage
Childhood apraxia of speech (CAS) is a motor speech disorder characterized by segmentation (increased segment and intersegment duration), speech sound distortions and equal lexical stress. This study examined the effects of four weeks of Treatment for Establishing Motor Program Organization (TEMPO) in inducing experience-based changes in the brain. A fMRI resting state functional connectivity analysis was used in a single-subject pre- and post-TEMPO to quantify the changes associated with this treatment. Increases in connectivity strength between specific regions of the brain were observed, with the largest change in connectivity strength occurring between the left and right ventral premotor cortex (vPMC). These regions are known to be involved in speech motor programming. These results demonstrate the efficacy of TEMPO in inducing experience-based neural plastic changes, as well as provide the first data supporting the involvement of the left ventral premotor cortex in CAS.
James, Morgan, "ASSESSING FUNCTIONAL CONNECTIVITY OF THE NEURAL NETWORKS IN CHILDHOOD APRAXIA OF SPEECH
USING RESTING STATE FMRI FOLLOWING THE TREATMENT FOR ESTABLISHING MOTOR PROGRAM ORGANIZATION
(TEMPO)" (2019). Master's Theses and Capstones. 1274.