Susceptibility to spontaneous atherosclerosis in pigeons: An autosomal recessive trait
The inheritance pattern for susceptibility to spontaneous (noninduced) aortic atherosclerosis in pigeons was determined by crossbreeding and backcrossing experiments with atherosclerosis-susceptible White Carneau and atherosclerosis-resistant Show Racer breeds. Susceptibility, assessed by the presence of grossly visible lesions at the celiac bifurcation of the aorta at 3 years of age, demonstrated an inheritance pattern consistent with an autosomal recessive Mendelian trait. Cell culture studies indicated that susceptibility is a constitutive property of aortic cells as evidenced by vacuole formation and lipid content in smooth muscle cells from various tissues in susceptible pigeons.
Journal of Heredity
Oxford University Press
Digital Object Identifier (DOI)
Scientific Contribution Number
Smith, S. C.; Smith, E. C.; and Taylor, R. L. Jr., "Susceptibility to spontaneous atherosclerosis in pigeons: An autosomal recessive trait" (2010). Journal of Heredity. 114.
© 2001 The American Genetic Association