Spectroscopic investigation of biomolecular dynamics using light scattering methods


All atoms scatter light in a manner that derives from their physical properties, such as whether they are moving together in a group with other atoms, part of a regular or irregular arrangement of atoms, or how quickly they are moving. This chapter reviews how the phenomenon of light scattering can be used to investigate the dynamics of biomacromolecules in solution. By highlighting recent applications of light scattering methods to proteins and nucleic acids and pointing the reader to valuable resources, it aims to inspire new research ideas and reduce barriers to collaboration. The chapter focuses on applications of light scattering in protein folding and unfolding, disorder, and conformational fluctuations to provide an update on select recent advances and ideas for future directions.

Publication Date


Journal Title

Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics



Document Type

Book Chapter


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