https://dx.doi.org/10.1016/0005-2728(90)90249-4">
 

Title

A plasmid-encoded anion-translocating ATPase

Abstract

An anion-translocating ATPase has been identified as the product of the arsenical resistance operon of resistance plasmid R773. When expressed in Escherichia coli this ATP-driven oxyanion pump catalyzes extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit enzyme produces resistance to arsenite and antimonite. A third gene, arsC, expands the substrate specificity to allow for arsenate pumping and resistance.

Publication Date

7-1-1990

Journal Title

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Publisher

Elsevier

Digital Object Identifier (DOI)

https://dx.doi.org/10.1016/0005-2728(90)90249-4

Document Type

Article

Rights

© 1990 Published by Elsevier B.V.

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