Purification of Aphanizomenon flos-aquae toxin and its chemical and physiological properties
A toxin in chromatographically pure form has been isolated from natural blooms of the blue-green alga Aphanizomenon flos-aquae. The toxin is a strongly basic substance, which gives a positive ninhydrin reaction and appears to be a guanidine derivative. A dose of 2·7 μg injected intraperitoneally into 20 g mice caused death in 4·9 min. The purified toxin reversibly blocks action potentials and tension development in amphibian nerve-muscle preparations without alteration of the resting potential. The toxin differs from saxitoxin in some of its chemical and physical properties, and some of its effects on neuromuscular systems.
Digital Object Identifier (DOI)
Alam, M., M. Ikawa, J.J. Sasner, Jr. and P.J. Sawyer. 1973. Purification of Aphanizomenon flos-aquae toxin and its chemical and physiological properties. Toxicon 11:65-72.
Copyright © 1973 Published by Elsevier Ltd.