Honors Theses and Capstones

Date of Award

Spring 2025

Project Type

Senior Honors Thesis

College or School

COLSA

Department

Department of Molecular, Cellular, and Biomedical Sciences

Program or Major

Biomedical Science: Medical Microbiology

Degree Name

Bachelor of Science

First Advisor

Vicki Jeffers

Abstract

The mouth, often referred to as the oral cavity in scientific literature, is described as the second most diversely populated microbiome in the human body, only after the gut. The cavity’s temperature, abundant water, high nutrient levels, and diversity of sites are all critical factors that make the oral cavity a space booming with life. The mouth harbors over 700 species of bacteria, in addition to numerous fungi, viruses, and protozoa species. Together, when working in harmony, these species provide critical supports to the functions of the human body. When dysbiosis occurs, however, the overgrowth of a single species may cause catastrophic changes to the mouth, leading to numerous additional health concerns. This review will investigate the makeup of the healthy mouth and explore the factors that aid in its development and maintenance. Additionally, common species causing dysbiosis, including bacteria, fungi, and protozoans, will be explored. In considering the causes of dysbiosis, prevention of such will also be highlighted.

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