Cytomegalovirus and HLA-A, B, and DR locus interactions: Impact on renal transplant graft survival.

Authors

Mark A. Schnitzler, Washington University School of Medicine in St. Louis
Robert Woodward, University of New Hampshire - Main Campus
Daniel C. Brennan, Washington University School of Medicine in St. LouisFollow
Donn L. Phelan, Washington University School of Medicine in St. Louis
Edward Spitznagel, Washington University School of Medicine in St. Louis
Stuart B. Boxerman, Washington University School of Medicine in St. Louis
William L. Phelan, Washington University School of Medicine in St. Louis
Wm. Claiborne Dunagan, Washington University School of Medicine in St. Louis
Thomas C. Bailey, Washington University School of Medicine in St. Louis

Abstract

Abstract

Graft failure rates for renal transplantations performed between 1989 and 1994 and recorded in the US Renal Data System database were retrospectively evaluated for interactions between cytomegalovirus and HLA- A, B, and DR loci. Twelve significant interactions were observed. There were significantly greater risks of graft failure for the total effect of cytomegalovirus and donor or matched HLA-DR9, recipient or matched HLA-B-51, and matched HLA-B13. We conclude that further study of renal transplants with these combinations of cytomegalovirus and HLA loci is needed to determine whether the observed interactions should be taken into consideration when matching donors with recipients.

Department

Health Management and Policy

Publication Date

12-1997

Journal Title

American Journal of Kidney Diseases

Publisher

Elsevier

Digital Object Identifier (DOI)

10.1016/S0272-6386(97)90080-9

Document Type

Article

Recommended Citation

Schnitzler, M.A., Woodward, R.S., Brennan, D.C., Phelan, D.L., Spitznagel, E.L., Boxerman, S.B., Dunagan, W.C., Bailey, T.C. Cytomegalovirus and HLA-A, B, and DR locus interactions: Impact on renal transplant graft survival. (1997) American Journal of Kidney Diseases, 30 (6), pp.