Differential Response to Exercise in African Americans with High Levels of Inflammation
Purpose: Systemic inflammation, measured by C-reactive protein (CRP), is an important risk factor for cardiovascular disease (CVD) and mortality. We investigated whether aerobic exercise training (AEXT) affects African Americans with high inflammation (HI) the same way it does African Americans with low inflammation (LI) in terms of CVD risk factors.
Methods: 23 African Americans with CRP levels <3 mg/L (LI) and 14 African Americans with CRP ≥3 mg/L (HI) underwent six months of AEXT. Participants were sedentary, non-diabetic, non-smoking, with clinical blood pressure <160/100 mm Hg, were non-hyperlipidemic, had no signs of cardiovascular, renal, or pulmonary disease, and were not on medication. Measures included CD62E+ endothelial microparticles (EMPs), a measure of early stage endothelial dysfunction, as well as lipid and glucose profile, aerobic fitness, body composition, and blood pressure.
Ethnicity & Disease
Ethnicity & Disease, Inc.
Digital Object Identifier (DOI)
Kretzschmar J, Babbitt DM, Diaz KM, Feairheller DL, Sturgeon KM, Perkins AM, Veerabhadrappa P, Williamson ST, Ling C, Lee H, Grimm H, Thakkar S, Crabbe DL, Kashem MA, Brown MD. Differential Response to Exercise in African Americans with High Levels of Inflammation. Ethnicity & Disease. 27(3),233-240. 2017.