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African American ethnicity is an independent risk factor for exaggerated oxidative stress, which is related to inflammation, hypertension, and cardiovascular disease. Recently, we reported that in vitro oxidative stress and inflammation levels differ between African American and Caucasian human umbilical vein endothelial cells (HUVECs), African American HUVECs having higher levels of both. However, it remains to be shown whether the cells would respond differently to external stimuli.
Vascular Health and Risk Management
Digital Object Identifier (DOI)
Feairheller D, Park, Rizzo, Kim, Brown M. Racial differences in the responses to shear stress in human umbilical vein endothelial cells. Vasc Health Risk Manag. 2011;7:425-431 https://doi.org/10.2147/VHRM.S22435