Inflammatory Biomarkers are Improved Subsequent to an Aerobic Exercise Training Intervention in African Americans
African Americans (AA) have the highest prevalence of hypertension (HTN) in the world which may emanate from their predisposition to heightened endothelial inflammation. Long-term exposure of the endothelium to proinflammatory cytokines leads to increased oxidative stress, inflammation, and endothelial dysfunction which support an environment favoring HTN. It is thought that the balance between pro- and anti-inflammation plays a crucial role as a determinant of endothelial homeostasis and health. Positive associations between proinflammatory markers such as C-reactive protein (CRP) and interleukin-6 (IL-6) with HTN have been reported. Elevated circulating levels of the anti-inflammatory cytokine, interleukin-10 (IL-10) have been associated with improved endothelial function. In addition, aerobic exercise training (AEXT) has been associated with favorable endothelial adaptations.
American Heart Association, Inc.
Babbitt DM, Diaz KM, Feairheller DL, Sturgeon KM, Perkins AM, Veerabhadrappa P, Willliamson ST, Kretzschmar J, Ling C, Lee H, Grimm H, Brown MD. Inflammatory Biomarkers are Improved Subsequent to an Aerobic Exercise Training Intervention in African Americans. Hypertension. 62:A618. Supp. 2013.
© 2013 by American Heart Association, Inc.