eNOS Phosphorylation Under Flow-Mediated Shear Stress: Effects of Flow Pattern and Ambient Oxygen Concentration
Vascular endothelial cells (EC) are continuously exposed to flow-mediated shear stress, a friction force generated by flowing blood, which is increased during aerobic exercise. The flow-mediated shear stress is the most important physiological stimulus for the formation of nitric oxide (NO) via activation of endothelial nitric oxide synthase (eNOS). It has been demonstrated that flow-mediated shear stress modulates vascular structure and function, and is a major determinant for vascular remodeling and arterial tone, which depends primarily on NO produced by EC in response to shear stress. NO plays many essential roles including vessel relaxation, inhibition of apoptosis, and anti-inflammation. However, effects of flow patterns and ambient oxygen concentration on the eNOS activation and NO production are largely unknown.
Medicine & Science in Sports & Exercise
Digital Object Identifier (DOI)
Kim JS, Kim B, Feairheller DL, Brown MD, Park JY. eNOS Phosphorylation Under Flow-Mediated Shear Stress: Effects of Flow Pattern and Ambient Oxygen Concentration. Medicine & Science in Sports & Exercise. 43:5. Supp. 2011.
© 2011 American College of Sports Medicine