Photoreceptor Phosphodiesterase (PDE6): Activation and Inactivation Mechanisms During Visual Transduction in Rods and Cones, Rick H. Cote
Faculty Publications

Photoreceptor phosphodiesterase (PDE6): structure, regulatory mechanisms, and implications for treatment of retinal diseases, Rick H. Cote, Richa Gupta, Michael J. Irwin, Xin Wang
Faculty Publications

Structural Analysis of the Regulatory GAF Domains of cGMP Phosphodiesterase Elucidates the Allosteric Communication Pathway, Richa Gupta, Yong Liu, Huanchen Wang, Christopher T. Nordyke, Ryan Z. Puterbaugh, Wenjun Cui, Kriszatina Varga, Feixia Chu, Hengming Ke, Harish Vashisth, Rick H. Cote
Faculty Publications

The Molecular Architecture of Photoreceptor Phosphodiesterase 6 (PDE6) with Activated G Protein Elucidates the Mechanism of Visual Excitation, Michael J. Irwin, Richa Gupta, Xiongzhuo Gao, Karyn B. Cahill, Feixia Chu, Rick H. Cote
Faculty Publications

The N Termini of the Inhibitory γ-subunits of Phosphodiesterase-6 (PDE6) from Rod and Cone Photoreceptors Differentially Regulate Transducin-mediated PDE6 Activation, David C. Plachetzki, Xin Wang, Rick H. Cote
Faculty Publications

Molecular architecture of photoreceptor phosphodiesterase elucidated by chemical cross-linking and integrative modeling., Xiaohui Zeng-Elmore, Xiong-Zhou Gao, Ricardo Pellarin, Dina Schneidman-Duhovny, Xiu-Jun Zhang, Katie A. Kozacka, Yang Tang, Andrej Sali, Robert Chalkley, Rick H. Cote, Feixia Chu
Molecular, Cellular & Biomedical Sciences

Identification of Amino Acid Residues Responsible for the Selectivity of Tadalafil Binding to Two Closely Related Phosphodiesterases, PDE5 and PDE6, Karyn B. Cahill, Johnathon H. Quade, Karen L. Carleton, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Functional mapping of interacting regions of the photoreceptor phosphodiesterase (PDE6) γ-subunit with PDE6 catalytic dimer, transducin, and regulator of G-protein signaling9-1 (RGS9-1), Xiu-Jun Zhang, Xiong-Zhuo Gao, Wei Yao, Rick H. Cote
Molecular, Cellular & Biomedical Sciences

Characterization of Conformational Changes and Protein-Protein Interactions of Rod Photoreceptor Phosphodiesterase (PDE6), Suzanne L. Matte, Thomas M. Laue, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Phosphodiesterase 6H, cone-specific inhibitor, Xiu-Jun Zhang, Rick H. Cote
Molecular, Cellular & Biomedical Sciences

Phosphodiesterase 6C, cGMP-specific cone alpha', Karyn B. Cahill, Rick H. Cote
Molecular, Cellular & Biomedical Sciences

Phosphodiesterase 6D, cGMP-specific rod delta, Hannah J. Gitschier, Rick H. Cote
Molecular, Cellular & Biomedical Sciences

Structural Requirements of the Photoreceptor Phosphodiesterase gamma-Subunit for Inhibition of Rod PDE6 Holoenzyme and for Its Activation by Transducin, Xiu-Jun Zhang, Nikolai P. Skiba, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Function and regulation of photoreceptor phosphodiesterase (PDE6) in the visual signaling pathway., Rick H. Cote, Karyn B. Cahill
Molecular, Cellular & Biomedical Sciences

Probing the Catalytic Sites and Activation Mechanism of Photoreceptor Phosphodiesterase Using Radiolabeled Phosphodiesterase Inhibitors, Yu-Ting Liu, Suzanne L. Matte, Jackie D. Corbin, Sharron H. Francis, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Direct Allosteric Regulation between the GAF Domain and Catalytic Domain of Photoreceptor Phosphodiesterase PDE6, Xiu-Jun Zhang, Karyn B. Cahill, Arye Elfenbein, Vadim Y. Arshavsky, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

The cGMP signaling pathway in retinal photoreceptors and the central role of photoreceptor phosphodiesterase (PDE6)., Rick H. Cote
Molecular, Cellular & Biomedical Sciences

Photoreceptor phosphodiesterase (PDE6): a G-protein-activated PDE regulating visual excitation in rod and cone photoreceptor cells., Rick H. Cote
Molecular, Cellular & Biomedical Sciences

The glutamic acid-rich protein-2 (GARP2) is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties., Dana C. Pentia, Suzanne Hosier, Rick H. Cote
Molecular, Cellular & Biomedical Sciences

Rod and cone opsin families differ in spectral tuning domains but not signal transducing domains as judged by saturated evolutionary trace analysis., Karen L. Carleton, Tyrone C. Spady, Rick H. Cote
Molecular, Cellular & Biomedical Sciences

cGMP signaling in vertebrate retinal photoreceptor cells, Xiujun Zhang, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Cyclic Guanosine 5′-Monophosphate Binding to Regulatory GAF Domains of Photoreceptor Phosphodiesterase, Rick H. Cote
Molecular, Cellular & Biomedical Sciences

Purification of PDE6 isozymes from mammalian retina., Dana C. Pentia, Suzanne Hosier, Rachel A. Collupy, Benerly A. Valeriani, Rick H. Cote
Molecular, Cellular & Biomedical Sciences

Assay and functional properties of PrBP(PDEδ), a prenyl-binding protein interacting with multiple partners., Houbin Zhang, Suzanne Hosier, Jennifer M. Terew, Kai Zhang, Rick H. Cote, Wolfgang Baehr
Molecular, Cellular & Biomedical Sciences

Evaluation of the 17-kDa prenyl-binding protein as a regulatory protein for phototransduction in retinal photoreceptors, Angela W. Norton, Suzanne Hosier, Jennifer M. Terew, Ning Li, Anuradha Dhingra, Noga Vardi, Wolfgang Baehr, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Characteristics of Photoreceptor PDE (PDE6): similarities and differences to PDE5, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Regulation of cyclic nucleotide levels by sequestration., Jackie D. Corbin, Jun Kotera, Venkatesh Gopal, Rick H. Cote, Sharron H. Francis
Molecular, Cellular & Biomedical Sciences

Structure, function, and regulation of photoreceptor phosphodiesterase (PDE6)., Rick H. Cote
Molecular, Cellular & Biomedical Sciences

Regulation of photoreceptor phosphodiesterase (PDE6) by phosphorylation of its inhibitory gamma subunit re-evaluated, Michael J. Paglia, Hongmei Mou, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

The catalytic and GAF domains of the rod cGMP phosphodiesterase (PDE6) heterodimer are regulated by distinct regions of its inhibitory gamma subunit, Hongmei Mou, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Molecular organization of bovine rod cGMP-Phosphodiesterase 6., Jacques F. Kameni Tcheudji, Luc Lebeau, Noelle Virmaux, Carmen G. Maftei, Rick H. Cote, Claire Lugnier, Patrick Schultz
Molecular, Cellular & Biomedical Sciences

Mechanism of transducin activation of frog rod photoreceptor phosphodiesterase - Allosteric interactions between the inhibitory gamma subunit and the noncatalytic cGMP-binding sites, Angela W. Norton, Marc R. D'Amours, Hector J. Grazio, Tracy L. Hebert, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Kinetics and regulation of cGMP binding to noncatalytic binding sites on photoreceptor phosphodiesterase, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Regulation of photoreceptor phosphodiesterase catalysis by its non-catalytic cGMP-binding sites, Marc R. D'Amours, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

cGMP Binding to Noncatalytic Sites on Mammalian Rod Photoreceptor Phosphodiesterase Is Regulated by Binding of Its γ and δ Subunits, Hongmei Mou, Hector J. Grazio, Terry A. Cooks, Joseph A. Beavo, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Structural Features of the Noncatalytic cGMP Binding Sites of Frog Photoreceptor Phosphodiesterase Using cGMP Analogs, Marcia C. Hebert, Frank Schwede, Bernd Jastorff, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Photoreceptor phosphodiesterase: Interaction of inhibitory γ subunit and cyclic GMP with specific binding sites on catalytic subunits., Nikolai O. Artemyev, Vadim Y. Arshavsky, Rick H. Cote
Molecular, Cellular & Biomedical Sciences

cGMP binding sites on photoreceptor phosphodiesterase: role in feedback regulation of visual transduction., Rick H. Cote, M Deric Bownds, Vadim Y. Arshavsky
Molecular, Cellular & Biomedical Sciences

Regulation of intracellular cyclic GMP concentration by light and calcium in electropermeabilized rod photoreceptors., V J. Coccia, Rick H. Cote
Molecular, Cellular & Biomedical Sciences

Intracellular cGMP concentration in rod photoreceptors is regulated by binding to high and moderate affinity cGMP binding sites., Rick H. Cote
Molecular, Cellular & Biomedical Sciences

Characterization of guanylate cyclase in squid photoreceptors., Phylis R. Robinson, Rick H. Cote
Molecular, Cellular & Biomedical Sciences

Cyclic GMP levels and membrane current during onset, recovery, and light adaptation of the photoresponse of detached frog photoreceptors., Rick H. Cote, Grant D. Nicol, Sheila A. Burke, M Deric Bownds
Molecular, Cellular & Biomedical Sciences

cGMP influences guanine nucleotide binding to frog photoreceptor G-protein., Phylis R. Robinson, Monte J. Radeke, Rick H. Cote, M Deric Bownds
Molecular, Cellular & Biomedical Sciences

Changes in cGMP concentration correlate with some, but not all, aspects of the light-regulated conductance of frog rod photoreceptors., Rick H. Cote, Grant D. Nicol, Sheila A. Burke, M Deric Bownds
Molecular, Cellular & Biomedical Sciences

Light-induced decreases in cGMP concentration precede changes in membrane permeability in frog rod photoreceptors., Rick H. Cote, Michael S. Biernbaum, Grant D. Nicol, M Deric Bownds
Molecular, Cellular & Biomedical Sciences

Formulation of the general rate equation for subunit flux at steady-state., Rick H. Cote, Charles F. Anderson, Gary G. Borisy
Molecular, Cellular & Biomedical Sciences

Head-to-tail polymerization of microtubules in vitro., Rick H. Cote, Gary G. Borisy
Molecular, Cellular & Biomedical Sciences

Release of Escherichia coli DNA from membrane complexes by single-strand endonucleases., M Abe, W G. Hendrickson, D H. Boyd, P Clifford, Rick H. Cote, M Schaechter
Molecular, Cellular & Biomedical Sciences