Photoreceptor Phosphodiesterase (PDE6): Activation and Inactivation Mechanisms During Visual Transduction in Rods and Cones, Rick H. Cote
Faculty Publications

Photoreceptor phosphodiesterase (PDE6): structure, regulatory mechanisms, and implications for treatment of retinal diseases, Rick H. Cote, Richa Gupta, Michael J. Irwin, Xin Wang
Faculty Publications

Structural Analysis of the Regulatory GAF Domains of cGMP Phosphodiesterase Elucidates the Allosteric Communication Pathway, Richa Gupta, Yong Liu, Huanchen Wang, Christopher T. Nordyke, Ryan Z. Puterbaugh, Wenjun Cui, Kriszatina Varga, Feixia Chu, Hengming Ke, Harish Vashisth, Rick H. Cote
Faculty Publications

The Molecular Architecture of Photoreceptor Phosphodiesterase 6 (PDE6) with Activated G Protein Elucidates the Mechanism of Visual Excitation, Michael J. Irwin, Richa Gupta, Xiongzhuo Gao, Karyn B. Cahill, Feixia Chu, Rick H. Cote
Faculty Publications

The N Termini of the Inhibitory γ-subunits of Phosphodiesterase-6 (PDE6) from Rod and Cone Photoreceptors Differentially Regulate Transducin-mediated PDE6 Activation, David C. Plachetzki, Xin Wang, Rick H. Cote
Faculty Publications

Identification of Amino Acid Residues Responsible for the Selectivity of Tadalafil Binding to Two Closely Related Phosphodiesterases, PDE5 and PDE6, Karyn B. Cahill, Johnathon H. Quade, Karen L. Carleton, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Characterization of Conformational Changes and Protein-Protein Interactions of Rod Photoreceptor Phosphodiesterase (PDE6), Suzanne L. Matte, Thomas M. Laue, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Phosphodiesterase 6H, cone-specific inhibitor, Xiu-Jun Zhang, Rick H. Cote
Molecular, Cellular & Biomedical Sciences

Phosphodiesterase 6C, cGMP-specific cone alpha', Karyn B. Cahill, Rick H. Cote
Molecular, Cellular & Biomedical Sciences

Phosphodiesterase 6D, cGMP-specific rod delta, Hannah J. Gitschier, Rick H. Cote
Molecular, Cellular & Biomedical Sciences

Structural Requirements of the Photoreceptor Phosphodiesterase gamma-Subunit for Inhibition of Rod PDE6 Holoenzyme and for Its Activation by Transducin, Xiu-Jun Zhang, Nikolai P. Skiba, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Probing the Catalytic Sites and Activation Mechanism of Photoreceptor Phosphodiesterase Using Radiolabeled Phosphodiesterase Inhibitors, Yu-Ting Liu, Suzanne L. Matte, Jackie D. Corbin, Sharron H. Francis, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Direct Allosteric Regulation between the GAF Domain and Catalytic Domain of Photoreceptor Phosphodiesterase PDE6, Xiu-Jun Zhang, Karyn B. Cahill, Arye Elfenbein, Vadim Y. Arshavsky, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

cGMP signaling in vertebrate retinal photoreceptor cells, Xiujun Zhang, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Evaluation of the 17-kDa prenyl-binding protein as a regulatory protein for phototransduction in retinal photoreceptors, Angela W. Norton, Suzanne Hosier, Jennifer M. Terew, Ning Li, Anuradha Dhingra, Noga Vardi, Wolfgang Baehr, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Characteristics of Photoreceptor PDE (PDE6): similarities and differences to PDE5, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Regulation of photoreceptor phosphodiesterase (PDE6) by phosphorylation of its inhibitory gamma subunit re-evaluated, Michael J. Paglia, Hongmei Mou, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

The catalytic and GAF domains of the rod cGMP phosphodiesterase (PDE6) heterodimer are regulated by distinct regions of its inhibitory gamma subunit, Hongmei Mou, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Mechanism of transducin activation of frog rod photoreceptor phosphodiesterase - Allosteric interactions between the inhibitory gamma subunit and the noncatalytic cGMP-binding sites, Angela W. Norton, Marc R. D'Amours, Hector J. Grazio, Tracy L. Hebert, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Kinetics and regulation of cGMP binding to noncatalytic binding sites on photoreceptor phosphodiesterase, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Regulation of photoreceptor phosphodiesterase catalysis by its non-catalytic cGMP-binding sites, Marc R. D'Amours, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

cGMP Binding to Noncatalytic Sites on Mammalian Rod Photoreceptor Phosphodiesterase Is Regulated by Binding of Its γ and δ Subunits, Hongmei Mou, Hector J. Grazio, Terry A. Cooks, Joseph A. Beavo, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Structural Features of the Noncatalytic cGMP Binding Sites of Frog Photoreceptor Phosphodiesterase Using cGMP Analogs, Marcia C. Hebert, Frank Schwede, Bernd Jastorff, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications