Using Spatial Transcriptomics to Understand Renal Function in Desert Rodents, Sarah Nicholls, Molly Kephart
Undergraduate Research Conference (URC) Student Presentations

Identification of Novel Biosynthetic Gene Clusters Encoding for Polyketide/NRPs-Producing Chemotherapeutic Compounds from Marine-Derived Streptomyces hygroscopicus from a Marine Sanctuary, Hannah Ruth Flaherty
Honors Theses and Capstones

Investigation of Mechanical Regulation on STAT3 Activity and MMP Production, Jaxson R. Libby
Honors Theses and Capstones

Investigating the Main Protease (MPro) of SARS-CoV-2 as a Potential Drug Target, Valerie Giovina Pascetta
Honors Theses and Capstones

Characterization of L-malic acid-capped CdS Quantum Dots and Examination of the Nanoncrystal's Biosensor Ability, Andrei A. Potapenko
Honors Theses and Capstones

Photoreceptor Phosphodiesterase (PDE6): Activation and Inactivation Mechanisms During Visual Transduction in Rods and Cones, Rick H. Cote
Faculty Publications

SARS-CoV-2: An Investigation on Mutagenicity and its Effects on Infectivity and Mortality, Tyler Elliott Silverwood
Honors Theses and Capstones

Photoreceptor phosphodiesterase (PDE6): structure, regulatory mechanisms, and implications for treatment of retinal diseases, Rick H. Cote, Richa Gupta, Michael J. Irwin, Xin Wang
Faculty Publications

The Effect of Substrate Type on the Growth of Winter Rye Seeds in Manchester, New Hampshire, Maryam Ahmad
Undergraduate Research Conference (URC) Student Presentations

Structural Analysis of the Regulatory GAF Domains of cGMP Phosphodiesterase Elucidates the Allosteric Communication Pathway, Richa Gupta, Yong Liu, Huanchen Wang, Christopher T. Nordyke, Ryan Z. Puterbaugh, Wenjun Cui, Kriszatina Varga, Feixia Chu, Hengming Ke, Harish Vashisth, Rick H. Cote
Faculty Publications

“C1ORF150”: A Novel Regulator of JAK2 Kinase, and Candidate Tumor Suppressor in Human Blood Cell Progenitors, Tyler M. Wade
Honors Theses and Capstones

Comparing Amino Acid Sample Recovery for Heated vs. Non-heated N2 Reduction (An Amino Acid Method), Diane DeVries, Scott Greenwood, Stuart Grandy
Undergraduate Research Conference (URC) Student Presentations

The Molecular Architecture of Photoreceptor Phosphodiesterase 6 (PDE6) with Activated G Protein Elucidates the Mechanism of Visual Excitation, Michael J. Irwin, Richa Gupta, Xiongzhuo Gao, Karyn B. Cahill, Feixia Chu, Rick H. Cote
Faculty Publications

The N Termini of the Inhibitory γ-subunits of Phosphodiesterase-6 (PDE6) from Rod and Cone Photoreceptors Differentially Regulate Transducin-mediated PDE6 Activation, David C. Plachetzki, Xin Wang, Rick H. Cote
Faculty Publications

Is the expression of tissue-degrading enzymes in the skeletal muscle of spiny dogfish correlated to capture stress?, Elizabeth Faircloth
Undergraduate Research Conference (URC) Student Presentations

Characterization of Cholecystokinin-Expressing Neurons in Sensory Areas of Spinal Cord and Trigeminal Nucleus, Sumeet Panesar, Zachary Tepper
Undergraduate Research Conference (URC) Student Presentations

Regulation of the Angiogenic Inducer, CCN1, in the Bovine Corpus Luteum: A Preliminary Study, Sarah M. Piet, Michael R. Goulet, Jake R. Donahue, Joseph M. Miseirvitch
Undergraduate Research Conference (URC) Student Presentations

Microwave-Assisted Glycosaminoglycans Labeling Using 1-phenyl-3-methyl-5-pyrazolone Followed by MALDI-TOF-MS Analysis, Avianna Guerrero
Undergraduate Research Conference (URC) Student Presentations

Expression and purification of human cone PDE6 GAF constructs, Christopher Olivier
Undergraduate Research Conference (URC) Student Presentations

Optimization of pAkt Expression and Detection in Bovine Granulosa Cells, Sarah M. Piet, David H. Townson PhD, Paul C. Tsang PhD
Undergraduate Research Conference (URC) Student Presentations

Investigations into the use of ALDEFLUOR® as an alternative method to classify leukemia in the soft-shell clam Mya arenaria., Katherine F. Norwood
Student Research Projects

Investigations into Aldefluor as a Novel Method for Identifying Leukemia in Soft-Shell Clams, Katherine F. Norwood
Student Research Projects

Exploring the Importance of Single Nucleotide Polymorphisms of HSPA9 in DNA of Sarcoma Patients, Christine M. Hebert
Honors Theses and Capstones

Identification of Amino Acid Residues Responsible for the Selectivity of Tadalafil Binding to Two Closely Related Phosphodiesterases, PDE5 and PDE6, Karyn B. Cahill, Johnathon H. Quade, Karen L. Carleton, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Minireview: Protein Interactions, Jessica Child
Honors Theses and Capstones

Characterization of Conformational Changes and Protein-Protein Interactions of Rod Photoreceptor Phosphodiesterase (PDE6), Suzanne L. Matte, Thomas M. Laue, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Profiling the aminopropyltransferases in plants: their structure, expression and manipulation, Lin Shao, Rajtilak Majumdar, Subhash C. Minocha
New Hampshire Agricultural Experiment Station Publications

Living with high putrescine: expression of ornithine and arginine biosynthetic pathway genes in high and low putrescine producing poplar cells, Andrew F. Page, Rakesh Minocha, Subhash C. Minocha
New Hampshire Agricultural Experiment Station Publications

SPT5 affects the rate of mRNA degradation and physically interacts with CCR4 but does not control mRNA deadenylation, Yajun Cui, Yueh-Chin Chiang, Palaniswamy Viswanathan, Darren J. Lee, Clyde L. Denis
New Hampshire Agricultural Experiment Station Publications

Phosphodiesterase 6H, cone-specific inhibitor, Xiu-Jun Zhang, Rick H. Cote
Molecular, Cellular & Biomedical Sciences

Phosphodiesterase 6C, cGMP-specific cone alpha', Karyn B. Cahill, Rick H. Cote
Molecular, Cellular & Biomedical Sciences

Identification of cyclophilin-40-interacting proteins reveals potential cellular function of cyclophilin-40, Miki Susanto Park, Feixia Chu, Jinghang Xie, Yu Wang
New Hampshire Agricultural Experiment Station Publications

Large-Scale Experimental Studies Show Unexpected Amino Acid Effects on Protein Expression and Solubility in vivo in E. coli, W. Nicholson Price II, Samuel K. Handelman, John K. Everett, Saichiu N. Tong, Ana Bracic, Jon D. Luff, Victor Naumov, Thomas Acton, Philip Manor, Rong Xiao, Burkhard Rost, Gaetano T. Montelione, John F. Hunt
Law Faculty Scholarship

A messenger molecule governs interdependency in an evolved Pseudomonas aeruginosa biofilm community, Thomas MacElliott Johnson
Honors Theses and Capstones

Phosphodiesterase 6D, cGMP-specific rod delta, Hannah J. Gitschier, Rick H. Cote
Molecular, Cellular & Biomedical Sciences

PUF3 Acceleration of Deadenylation in Vivo Can Operate Independently of CCR4 Activity, Possibly Involving Effects on the PAB1-mRNP Structure, Darren Lee, Takbum Ohn, Yueh-Chin Chiang, Gloria Quigley, Gang Yao, Yuting Liu, Clyde L. Denis
New Hampshire Agricultural Experiment Station Publications

Transgenic manipulation of a single polyamine in poplar cells affects the accumulation of all amino acids, Sridev Mohapatra, Rakesh Minocha, Stephanie Long, Subhash C. Minocha
New Hampshire Agricultural Experiment Station Publications

Polyamines and cellular metabolism in plants: transgenic approaches reveal different responses to diamine putrescine versus higher polyamines spermidine and spermine, Autar A. Mattoo, Subhash C. Minocha, Rakesh Minocha, Avtar K. Handa
New Hampshire Agricultural Experiment Station Publications

Structural Requirements of the Photoreceptor Phosphodiesterase gamma-Subunit for Inhibition of Rod PDE6 Holoenzyme and for Its Activation by Transducin, Xiu-Jun Zhang, Nikolai P. Skiba, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Probing the Catalytic Sites and Activation Mechanism of Photoreceptor Phosphodiesterase Using Radiolabeled Phosphodiesterase Inhibitors, Yu-Ting Liu, Suzanne L. Matte, Jackie D. Corbin, Sharron H. Francis, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

The zinc finger protein Zn72D and DEAD box helicase Belle interact and control maleless mRNA and protein levels, Kathleen A. Worringer, Feixia Chu, Barbara Panning
Molecular, Cellular & Biomedical Sciences

Understanding the Physical Properties that Control Protein Crystallization by Analysis of LargeScale Experimental Data, W. Nicholson Price II, Yang Chen, Samuel K. Handelman, Helen Neely, Philip Manor, Richard Karlin, Rajesh Nair, Jinfeng Liu, Michael Baran, John Everett, Saichiu N. Tong, Farhad Forouhar, Swarup S. Swaminathan, Thomas Acton, Rong Xiao, Joseph R. Luft, Angela Lauricella, George T. DeTitta, Burkhard Rost, Gaetano T. Montelione, John T. Hunt
Law Faculty Scholarship

Direct Allosteric Regulation between the GAF Domain and Catalytic Domain of Photoreceptor Phosphodiesterase PDE6, Xiu-Jun Zhang, Karyn B. Cahill, Arye Elfenbein, Vadim Y. Arshavsky, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Comparative reliability and sensitivity of different methods for assessing treatment effects on sperm production, William E. Berndtson
New Hampshire Agricultural Experiment Station Publications

Drug Resistance in Malaria: A Peruvian Research Experience, Ryan Haley
Inquiry Journal 2008

A dual fluorescence flow cytometric analysis of bacterial adherence to mammalian host cells, Bochiwe Hara-Kaonga, Thomas G. Pistole
New Hampshire Agricultural Experiment Station Publications

CAF1 plays an important role in mRNA deadenylation separate from its contact to CCR4, Takbum Ohn, Yueh-Chin Chiang, Darren J. Lee, Gang Yao, Chongxu Zhang, Clyde L. Denis
Molecular, Cellular & Biomedical Sciences

cGMP signaling in vertebrate retinal photoreceptor cells, Xiujun Zhang, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Evaluation of the 17-kDa prenyl-binding protein as a regulatory protein for phototransduction in retinal photoreceptors, Angela W. Norton, Suzanne Hosier, Jennifer M. Terew, Ning Li, Anuradha Dhingra, Noga Vardi, Wolfgang Baehr, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

OmpD but not OmpC is involved in adherence of Salmonella enterica serovar Typhimurium to human cells, Bochiwe Hara-Kaonga, Thomas G. Pistole
New Hampshire Agricultural Experiment Station Publications

Characteristics of Photoreceptor PDE (PDE6): similarities and differences to PDE5, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Localization of the ethylene receptor ETR1 to the endoplasmic reticulum of Arabidopsis, Yi-Feng Chen, Melynda D. Randlett, Jennifer L. Findell, G. Eric Schaller
New Hampshire Agricultural Experiment Station Publications

Regulation of photoreceptor phosphodiesterase (PDE6) by phosphorylation of its inhibitory gamma subunit re-evaluated, Michael J. Paglia, Hongmei Mou, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex, Junji Chen, Juri Rappsilber, Yueh-Chin Chiang, Pamela Russell, Matthias Mann, Clyde L. Denis
New Hampshire Agricultural Experiment Station Publications

The catalytic and GAF domains of the rod cGMP phosphodiesterase (PDE6) heterodimer are regulated by distinct regions of its inhibitory gamma subunit, Hongmei Mou, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Mechanism of transducin activation of frog rod photoreceptor phosphodiesterase - Allosteric interactions between the inhibitory gamma subunit and the noncatalytic cGMP-binding sites, Angela W. Norton, Marc R. D'Amours, Hector J. Grazio, Tracy L. Hebert, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Biodegradable dissolved organic carbon in forest soil solution and effects of chronic nitrogen deposition, Y. Yano, William H. McDowell, J. D. Aber
New Hampshire Agricultural Experiment Station Publications

Kinetics and regulation of cGMP binding to noncatalytic binding sites on photoreceptor phosphodiesterase, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Species-specific nuclear and chloroplast single nucleotide polymorphisms to distinguish Picea glauca, P. mariana and P. rubens, J. Germano, Anita S. Klein
New Hampshire Agricultural Experiment Station Publications

Regulation of photoreceptor phosphodiesterase catalysis by its non-catalytic cGMP-binding sites, Marc R. D'Amours, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

cGMP Binding to Noncatalytic Sites on Mammalian Rod Photoreceptor Phosphodiesterase Is Regulated by Binding of Its γ and δ Subunits, Hongmei Mou, Hector J. Grazio, Terry A. Cooks, Joseph A. Beavo, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Biogeochemistry of Gulf of Mexico Estuaries, Thomas S. Bianchi, Jonathan Pennock, Robert R. Twilley
School of Marine Science and Ocean Engineering

Structural Features of the Noncatalytic cGMP Binding Sites of Frog Photoreceptor Phosphodiesterase Using cGMP Analogs, Marcia C. Hebert, Frank Schwede, Bernd Jastorff, Rick H. Cote
New Hampshire Agricultural Experiment Station Publications

Metabolism of Polyamines in Transgenic Cells of Carrot Expressing a Mouse Ornithine Decarboxylase cDNA, Scott E. Andersen, Dhundy R. Bastola, Subhash C. Minocha
New Hampshire Agricultural Experiment Station Publications

Sequence variation in the outer-surface-protein genes of Borrelia burgdorferi, Diane A. Caporale, Thomas D. Kocher
New Hampshire Agricultural Experiment Station Publications

Cathepsin G and thrombin: evidence for two different platelet receptors, Mary A. Selak
New Hampshire Agricultural Experiment Station Publications

ADR1c mutations enhance the ability of ADR1 to activate transcription by a mechanism that is independent of effects on cyclic AMP-dependent protein kinase phosphorylation of Ser-230, Clyde L. Denis, Susan C. Fontaine, Dan Chase, Bruce E. Kemp, Lynne T. Bemis
New Hampshire Agricultural Experiment Station Publications

Substrate specificities for yeast and mammalian cAMP-dependent protein kinases are similar but not identical, Clyde L. Denis, Bruce E. Kemp, Mark J. Zoller
New Hampshire Agricultural Experiment Station Publications

Comparative molecular properties of swine and human very low density lipoproteins—Apoproteins E and C, Arthur F. Stucchi, Jose M. Ordovas, Glenn T. Shwaery, Samuel C. Smith
New Hampshire Agricultural Experiment Station Publications