Zinc Carbenoid-mediated Chain Extension of β-Keto Amides
The reaction of β-keto amides with ethyl(iodomethyl)zinc provides access to a wide variety of γ-keto amides, including primary, secondary, and tertiary amides. Although the reaction of α-substituted β-keto amides are in many cases unsatisfactory, the method can be applied to a broad spectrum of substrates that possess imide and olefinic functionality.
Digital Object Identifier (DOI)
Zinc Carbenoid-mediated Chain Extension of b-Keto Amides, Hilgenkamp, R.; Zercher, C. K. Tetrahedron 2001, 57, 8793-8800.
Copyright © 2001, Elsevier