Olefin Cross-Metathesis in the Preparation of Polycyclopropanes: Formal Synthesis of FR-900848
Olefin cross-metathesis was used for the efficient incorporation of an E-olefin between two cyclopropane residues. The generation of a bis-cyclopropyl alkene homodimer, followed by cross metathesis with a terminal vinyl polycyclopropane, provided excellent yields of the targeted compounds with good olefin stereoselectivity. The strategy was applied to generation of a quinta-cyclopropane intermediate found in a previous synthesis of the natural product FR-900848.
Digital Object Identifier (DOI)
Olefin Cross-Metathesis in the Preparation of Polycyclopropanes: Formal Synthesis of FR-900848, Verbicky, C. A.; Zercher, C. K. Tetrahedron Lett. 2000, 41, 8723-8727.
Copyright © 2000, Elsevier