Diamond Microelectrodes and CMOS Microelectronics for Wireless Transmission of Fast-Scan Cyclic Voltammetry


This paper reports on technology development at the sensor and circuit levels for wireless transmissionof fast- scan cyclic voltammetry (FSCV) in neurochemical detection. Heavily conductive, boron-dopeddiamond is selectively deposited onto the polished tip of a tungsten microelectrode to fabricate versatile, implantable, micro-needle microprobes capable of neurochemical sensing in the brain. In addition, an integrated circuit is fabricated in a 0.5-mum CMOS technology for processing and wirelesstransmission of the electrochemical signals corresponding to extracellular concentration changes of various neurotransmitters. The chip consists of a current-based, second-order, front-end SigmaDelta ADC and an on-chip, RF-FSK transmitter at the back-end. The ADC core and the transmitter consume 22 muA and 400 muA, respectively, from a 2.6-V power supply. Major electroactive neurotransmitters such as serotonin and dopamine in micromolar concentration have been wirelessly recorded at 433 MHz using 300-V/s FSCV in flow injection analysis experiments.


Chemical Engineering

Publication Date


Journal Title

Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE



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Conference Proceeding