Immunological functions of avian alloantigens
13 chicken alloantigen systems, originally found on erythrocytes, have been identified using serological methods. These systems include: A, B, C, D, E, H, I, J, K, L, N, P and R. The B complex, which is the chicken major histocompatibility complex (MHC), is the best characterized of these systems. Significant effects on the outcome of viral (Rous sarcoma, Marek's disease and lymphoid leukosis), parasitic (coccidiosis) and bacterial (Pasteurella multocida, Staphylococcus aureus and Salmonella enteritidis) infections and autoimmune diseases indicated the importance of the role of the B complex in immune processes. Some of the remaining 12 alloantigen systems have shown an association with immune parameters such as antibody response, macrophage function and disease outcome, including the fate of Rous sarcoma and caecal coccidiosis (caused by Eimeria tenella). The future investigation of avian alloantigens promises to clarify their precise immune functions and to reveal the processes underlying differential disease outcome.
Recent research developments in infection & immunity
Transworld Research Network
Scientific Contribution Number
Medarova, Z., Briles, W.E. and Taylor, R.L. Jr. "Immunological functions of avian alloantigens." S.G. Pandalai (Ed.), Recent Research Developments in Infection & Immunity. 2003; 1:145-166.