https://dx.doi.org/10.1523/JNEUROSCI.2180-12.2012">
 

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Abstract

Cilia of olfactory sensory neurons are the primary sensory organelles for olfaction. The detection of odorants by the main olfactory epithelium (MOE) depends on coupling of odorant receptors to the type 3 adenylyl cyclase (AC3) in olfactory cilia. We monitored the effect of airflow on electro-olfactogram (EOG) responses and found that the MOE of mice can sense mechanical forces generated by airflow. The airflow-sensitive EOG response in the MOE was attenuated when cAMP was increased by odorants or by forskolin suggesting a common mechanism for airflow and odorant detection. In addition, the sensitivity to airflow was significantly impaired in the MOE from AC3−/− mice. We conclude that AC3 in the MOE is required for detecting the mechanical force of airflow, which in turn may regulate odorant perception during sniffing.

Publication Date

11-7-2012

Journal Title

Journal of Neuroscience

Publisher

Society for Neuroscience

Digital Object Identifier (DOI)

https://dx.doi.org/10.1523/JNEUROSCI.2180-12.2012

Document Type

Article

Rights

© 2012 the authors

Comments

This is an article published by Society for Neuroscience in Journal of Neuroscience in 2012, available online: https://dx.doi.org/10.1523/JNEUROSCI.2180-12.2012

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