https://dx.doi.org/10.1523/JNEUROSCI.2478-14.2015">
 

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Abstract

The type 1 adenylyl cyclase (AC1) is an activity-dependent, calcium-stimulated adenylyl cyclase expressed in the nervous system that is implicated in memory formation. We examined the locomotor activity, and impulsive and social behaviors of AC1+ mice, a transgenic mouse strain overexpressing AC1 in the forebrain. Here we report that AC1+ mice exhibit hyperactive behaviors and demonstrate increased impulsivity and reduced sociability. In contrast, AC1 and AC8 double knock-out mice are hypoactive, and exhibit increased sociability and reduced impulsivity. Interestingly, the hyperactivity of AC1+ mice can be corrected by valproate, a mood-stabilizing drug. These data indicate that increased expression of AC1 in the forebrain leads to deficits in behavioral inhibition.

Publication Date

1-7-2015

Journal Title

Journal of Neuroscience

Publisher

Society for Neuroscience

Digital Object Identifier (DOI)

https://dx.doi.org/10.1523/JNEUROSCI.2478-14.2015

Document Type

Article

Rights

© 2015 the authors

Comments

This is an article published by Society for Neuroscience in Journal of Neuroscience in 2015, available online: https://dx.doi.org/10.1523/JNEUROSCI.2478-14.2015

Share

COinS