Honors Theses and Capstones

Epigenetic Regulation of Rett Syndrome in a Mouse Model

Taylor Hickman, University of New Hampshire

Abstract

Rett Syndrome is a neurodevelopmental disorder that is thought to be caused by epigenetic dysregulation of the Methyl-CpG binding protein 2 gene (MeCP2). One means of epigenetic change is through post-translational histone modifications that alter the structure of chromatin and consequently alter gene expression.To investigate the state of chromatin, metabolic labeling and mass spectrometric analysis were utilized to identify and quantify post-translational histone modifications in MeCP2 wild type and knock out mouse brains.